https://stacks.cdc.gov/view/cdc/37676/cdc_37676_DS1.pdf

Toxicological Profile for Lead

Guidelines for Canadian Drinking Water Quality

Organotin compounds are ubiquitous contaminants in the environment. The high biological activity of some compounds toward aquatic organisms lead to deleterious impacts in aquatic ecosystems. Here, the aquatic ecotoxicology of organotins is reviewed based on a multidisciplinary approach involving environmental chemical, toxicological, and ecological aspects. Basic results were obtained both with field and laboratory studies, and some of the most important recent results and conclusions are critically reviewed. The contamination of and fate in aquatic systems is reported and linked with effects at different levels of biological organization. Major emphasis is placed on the development of a concept of ecotoxicology that encompasses not only effect assessment alone, but also integrates environmental chemistry with aquatic toxicology. Thereby, the influence of speciation for bioavailability, basic modes of toxic action, and aquatic toxicity are discussed. This case study on organotins allows to a certain extent generalizations to ecotoxicology in general.

Ecotoxicology of organotin compounds.

Toxicological profile for arsenic

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which require costly hospitalization and ex...

/pdf/sarcopenia-aging-related-loss-of-muscle-mass-and-function-2u9nyjfrxt.pdf

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

The induction of renal tumours by feeding basic lead acetate to mice and hamsters.

Changes in the nervous system and musculature of normal 34-month-old rats are described. Wallerian degeneration as well as segmental demyelination were observed in the peripheral nervous system, with changes more severe in the sciatic than in the brachial nerves. Signs of nerve-fibre degeneration were also seen in the cord and lower brain stem. The degenerative changes were usually mild, but in a number of animals there was severe degeneration of the gracile tract and lateral columns. Other changes in the nervous system included lipochrome pigment in nerve cells and other cellular elements throughout brain and cord, and eosinophilic bodies in the lower brain stem and cord. In some animals the ventricular system in the brain was dilated. Changes in the skeletal musculature were believed to represent neurogenic muscular atrophy secondary to changes in the nervous system.

R. Kroes

Papers

The induction of renal tumours by feeding basic lead acetate to mice and hamsters.

Changes in the Nervous System and Musculature of Old Rats

Long term toxicity and reproduction study (including a teratogenicity study) with cyclamate, saccharin and cyclohexylamine.

Spontaneous tumours in the pituitary gland of old Wistar rats. A morphological and immunocytochemical study

Semichronic toxicity study of sodium bromide in rats