Nocturnal hypoxemia is common in primary pulmonary hypertension.

Sleep is important for health and quality of life at all ages, and poor sleep interacts with many medical conditions. Somatic and psychiatric diseases, and unfavourable habits and life-style factors, increase the propensity to insomnia in older persons. As health deteriorates with age, sleep becomes poorer. Heart disease and stroke, cancer, painful conditions, breathing disorders and nocturnal polyuria syndrome often disturb sleep. Dementia and depression, which are often associated with sleep disturbances, are also more prevalent in the elderly. Moreover, true age-related sleep deterioration occurs after the age of 75 years. Attempts to improve sleep should first and foremost be focused on elimination of somatic and psychiatric symptoms as far as possible, and on modification of lifestyle factors that may affect sleep quality. For short term treatment, hypnotics are appropriate; for longer periods, nonpharmacological methods, for example light therapy or behavioural modification techniques, should be considered, as many hypnotic drugs are less suitable for long term use. However, there are situations when sleep medication must continue for long periods, especially in elderly patients with severe diseases and poor quality of life. In these patients, careful individualisation of therapy is appropriate.

Sleep Disorders in the Elderly

Predictors of nocturnal oxygen desaturation in pulmonary arterial hypertension.

Potential mechanisms connecting asthma, esophageal reflux, and obesity/sleep apnea complex--a hypothetical review.

Aim Sleep-disturbed breathing (SDB) is common in pre-capillary pulmonary hypertension (PH) and impairs daytime performance. In lack of proven effective treatments, we tested whether nocturnal oxygen therapy (NOT) or acetazolamide improve exercise performance and quality of life in patients with pre-capillary PH and SDB.

Methods This was a randomized, placebo-controlled, double-blind, three period cross-over trial. Participants received NOT (3 L/min), acetazolamide tablets (2 × 250 mg), and sham-NOT/placebo tablets each during 1 week with 1-week washout between treatment periods. Twenty-three patients, 16 with pulmonary arterial PH, 7 with chronic thromboembolic PH, and with SDB defined as mean nocturnal oxygen saturation 10 h−1 with daytime PaO2 ≥7.3 kPa participated. Assessments at the end of the treatment periods included a 6 min walk distance (MWD), SF-36 quality of life, polysomnography, and echocardiography.

Results Medians (quartiles) of the 6 MWD after NOT, acetazolamide, and placebo were 480 m (390;528), 440 m (368;468), and 454 m (367;510), respectively, mean differences: NOT vs. placebo +25 m (95% CI 3–46, P = 0.027), acetazolamide vs. placebo −9 m (−34–17, P = 0.223), and NOT vs. acetazolamide +33 (12–45, P < 0.001). SF-36 quality of life was similar with all treatments. Nocturnal oxygen saturation significantly improved with both NOT and acetazolamide. Right ventricular fractional area change was greater on NOT compared with placebo ( P = 0.042) and acetazolamide ( P = 0.027).

Conclusions In patients with pre-capillary PH and SDB on optimized pharmacological therapy, NOT improved the 6 MWD compared with placebo already after 1 week along with improvements in SDB and haemodynamics.

ClinicalTrials.gov NTC01427192.

https://www.zora.uzh.ch/id/eprint/92662/1/eht540.pdf

Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with pre-capillary pulmonary hypertension and sleep-disturbed breathing: randomized, double-blind, cross-over trial

Patients with chronic obstructive pulmonary disease, kyphoscoliosis, and neuromuscular disorders frequently desaturate in rapid eye movement sleep. This can lead to polycythemia, pulmonary hypertension, and respiratory failure. In addition, these patients as well as those with asthma may have unsuspected coexistent obstructive sleep apnea. The detection of hypoventilation, oxygen desaturation, and obstructive sleep apnea may lead to more effective treatment of these patients.

R P Millman

Papers

Sleep disorders and outpatient treatment of patients with pulmonary disease.