R. Weise

TL;DR: It is suggested that cholesterol-lowering therapy with simvastatin may improve overall coronary vasodilator capacity assessed noninvasively by PET in patients with mild to moderate hypercholesterolemia and is considered a vasoprotective treatment for selected patients in very early stages of coronary atherosclerosis with the potential of preventing further disease progression.

TL;DR: Probably for the first time, a 30% improvement in coronary vasodilatation capacity could be demonstrated quantitatively and non-invasively by PET after a single LDL-A within 24 h.

TL;DR: Misalignment in the y-direction between SPECT and the attenuation map can lead to artifacts in the apical, septal, and anterior wall, which will appear as defects and there is evidence that mismatches along the other directions may have a similar effect.

TL;DR: Recovery correction is mandatory for 124I PET quantification, even for large structures to ensure accurate dosimetry, and thorough absolute recovery measurements must be individually established for the particular PET scanner and radionuclide to be used.

TL;DR: The x-ray-derived attenuation correction leads toSPECT images that represent myocardial perfusion more accurately than nonattenuation-corrected SPECT images, and the benefit of the method is seen primarily in the inferior wall.