Rafael V. Davalos

TL;DR: In this paper, a new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed, which involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the desired tissue.

TL;DR: Results of in vivo experiments that confirm the feasibility of a new minimally invasive method for tissue ablation, irreversible electroporation (IRE), and demonstrates that IRE can become an effective method for nonthermal tissueAblation requiring no drugs.

TL;DR: The first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice was reported, and induced complete regression in 12 out of 13 treated tumors, in the absence of tissue heating.

TL;DR: H-FIRE is a feasible technique for non-thermal tissue ablation that eliminates muscle contractions seen in IRE treatments performed with unipolar electric pulses and has the potential to be performed clinically without the administration of paralytic agents.

TL;DR: Two microfluidic devices capable of selectively isolating live human leukemia cells from dead cells utilizing their electrical signatures are presented, achieving greater than 95% removal efficiency and 100% selectivity between live and dead cells.