Showing papers by "Raffaele Dubbioso published in 2011"
TL;DR: It is confirmed that the SPG5 phenotype may be broader than pure presentation and electrophysiological evaluation could be very useful to address the molecular diagnosis and to follow-up a hypothetical treatment.
28 citations
TL;DR: Clinical and laboratory evaluations demonstrated postganglionic autonomic damage that could be related to a prolonged and severe impaired synaptic transmission and a somatic nerve fiber involvement in autoimmune autonomic ganglionopathy is reported for the first time to the authors' knowledge.
Abstract: Objective To evaluate postganglionic autonomic and somatic nerve fiber involvement in a patient with chronic autoimmune autonomic ganglionopathy. Design Case report. Setting Department of Neurological Sciences, University Federico II of Naples. Patient A patient with a 16-year history of severe autonomic failure and a high nicotinic acetylcholine receptor antibody titer underwent an extensive laboratory evaluation. Main Outcome Measures Evaluation of sympathetic and parasympathetic functions and sural nerve and skin biopsies. Results Clinical and laboratory evaluations showed the involvement of cardiovascular, pupillary, sudomotor, gastrointestinal, and bladder functions. Sudomotor function study and skin biopsy findings revealed postganglionic autonomic damage. Moreover, sural nerve and skin biopsy specimens provided clear evidence of somatic nerve fiber involvement. Conclusions We demonstrated postganglionic autonomic damage that could be related to a prolonged and severe impaired synaptic transmission and we report, for the first time to our knowledge, a somatic nerve fiber involvement in autoimmune autonomic ganglionopathy.
16 citations
2 citations
TL;DR: In this paper, Cogiamanian et al. discuss the neuro-neurotology and the disordini del movimento in the context of neurostimolazione.
1 citations