https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

13C NMR spectra of pentacyclic triterpenoids--a compilation and some salient features

Biological activities and distribution of plant saponins.

Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective effect on human health. Identifying bioactive dietary constituents is an active area of scientific investigation that may lead to new drug discovery. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g. tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries and grapes) and in plants or botanical products commonly used in traditional medicine (e.g. Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora japonica and propolis). Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. In this article, the distribution of kaempferol in the plant kingdom and its pharmacological properties are reviewed. The pharmacokinetics (e.g. oral bioavailability, metabolism, plasma levels) and safety of kaempferol are also analyzed. This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.

A review on the dietary flavonoid kaempferol.

Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

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Chalcone: A Privileged Structure in Medicinal Chemistry.

This study is a review of the Condamineeae tribe, through the acquisition of data from phytochemical studies and evaluation of genera activities that constitute the tribe, in order to contribute to chemotaxonomic classification of this tribe in the Rubiaceae family. This review also states the scarcity of phytochemical investigations of several genera and consequently a lot of species of family.

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Chemistry and Biological Activity of Condamineeae Tribe: A Chemotaxonomic Contribution of Rubiaceae Family

From the leaves of Solanum campaniforme, two new spirosolane alkaloids β-acetoxyl-(25S)-22βN-spirosol-4-en-3-one (1) and β-hydroxyl-(25S)-22βN-spirosol-4-en-3-one (4) were isolated along with two other known alkaloids of the same class (25S)-22βN-spirosol-1,4-dien-3-one (2) and (25S)-22βN-spirosol-4-en-3-one (3), which are reported for the first time as natural products. The structures of all alkaloids were established after an extensive analysis by 1D and 2D NMR spectroscopy (COSY, HSQC, HMBC and NOESY) as well as HRESIMS.

Structure elucidation and NMR assignments of new spirosolane alkaloids from Solanum campaniforme.

New triterpene glycoside and other chemical constituents from the leaves of Swartzia apetala Raddi var. glabra.

Flindersia brayleyana F. Muell. contains the diprenylated coumarins 1 and 2, in addition to the known coumarins braylin (3) and brayleyanin (4). The structures of the new natural products were elucidated by extensive NMR analysis and mass spectra.

Two new diprenylated coumarins from Flindersia brayleyana.

Borreria verticillata contains the new iridoid aglycone borreriagenin (1), in addition to the known iridoids asperuloside (2) and daphylloside (3). The structure of borreriagenin (1) was elucidated by extensive NMR analysis.

Raimundo Braz-Filho

Papers

Chemistry and Biological Activity of Condamineeae Tribe: A Chemotaxonomic Contribution of Rubiaceae Family

Structure elucidation and NMR assignments of new spirosolane alkaloids from Solanum campaniforme.

New triterpene glycoside and other chemical constituents from the leaves of Swartzia apetala Raddi var. glabra.

Two new diprenylated coumarins from Flindersia brayleyana.

Iridoids from Borreria verticillata.