This book succeeds Review of Medical Pharmacology , by Meyers, Jawetz, and Goldfien. Edited by B. G. Katzung, some of the important areas covered include drug receptors and pharmacodynamics, pharmacokinetics of absorption and biotransformation of drugs, autonomic pharmacology of cholinergic and adrenergic receptor stimulants and antagonists, antihypertensive agents, cardiac glycosides and other agents used in the treatment of congestive heart failure, therapeutic drugs for cardiac arrhythmias, diuretics, pharmacology of the CNS drugs such as anticonvulsants and anesthetics, antidepressants, narcotic analgesics, nonsteroidal anti-inflammatory agents, endocrine pharmacology, antimicrobial and antimycobacterial drugs, antiprotozoal and antihelmintic drugs, cancer chemotherapy, and drugs and the immune system. Written by several prominent researchers and scientists, each chapter begins with a section on the basic pharmacology, chemistry, pharmacokinetics, and pharmacodynamics of the agents under discussion. This is followed by a section on clinical pharmacology, which deals with relevant information regarding the clinical use of drugs on the various

Basic and Clinical Pharmacology

This study evaluates the whole plant ethanolic extract of two plants’ i.e., Withania somnifera Dunal (Ashwagandha) and Commiphora wightii (Arnott.) Bhandari (Guggul) for their hypolipidemic effects in high fat diet induced hyperlipidemic Wistar rats. After determining lethal dose (LD50), two defined doses of the two extracts i.e., 250 mg and 500 mg of extract per kg rat body weight, serum glucose, total cholesterol, triglyceride as well as plasma creatinine, urea, glutamic oxaloacetic transaminase, aspartate aminotransferase, glutamic pyruvic transaminase and alanine transaminase were evaluated. The main finding of the study demonstrated that both the extract perform effectiveness compared to atorvastatin in a dose dependent manner in prevention of hyperlipidemic condition and could promote a better health conditions. When comparing therapies for hyperlipidemia, the higher dose of W. somnifera and C. wightii plant extracts have shown improvements in body weight, lipid profile, glucose lev¬els, liver and kidney function.

https://www.thepharmajournal.com/archives/2018/vol7issue4/PartE/7-2-77-669.pdf

Raj Shree

Papers

Effect of dietary Withenia somnifera and Commiphora weightii on induced hyperlipidemic wistar rats