Diastolic dysfunction is the alteration or the decline in the activity of of the ventricular function. It affects affects the organ’s capacity to fill with an adequate amount of blood during diastole. These alterations involve active or passive relaxation. Acute hypertension, ischemia, Infarction, Aortic Stenosis, Idiopathic Hypertrophic Cardiomyopathy, Diabetes and Obesity are the common causes of diastolic dysfunction. Alterations in the myocardial diastolic properties lead to left ventricular diastolic dysfunction which finally leads to diastolic heart failure. In this review, several therapeutic appraches including pharmacologic, nonpharmacologic, and surgical approaches for the treatment of diastolic dysfunction and heart failure will be discussed.

Diastolic dysfunction and the Risk of Heart Failure: Therapeutics Approaches

Styloid process syndrome

Acute myeloid leukaemia (AML) is a life threatening hematologic malignancy. Despite a well-characterized genetic and molecular landscape, targeted therapies for AML have didn't considerably improve clinical outcomes. Over the past decade, proteasome inhibition has been incontestable to be a good therapeutic strategy in many medicine malignancies. Proteasome inhibitors, like bortezomib and carfilzomib, became mainstays of treatment for myeloma and mantle cell malignant neoplastic disease. In light-weight of this success, there has been a surge of literature exploring each the role of the proteasome and also the effects of proteasome inhibition in acute myeloid leukaemia. Pre-clinical studies have incontestable that proteasome inhibition disrupts proliferative cell sign pathways, exhibits cytotoxic synergism with different chemotherapeutics and induces autophagy of cancer-related proteins. Meanwhile, clinical trials incorporating bortezomib into combination therapy regimens have reported a variety of responses in AML patients, with complete remission rates. In a trial to focus additional investigation into this space, these recent studies and their findings are reviewed here.

A Review on Acute Myeloid Leukaemia

Anemia is a major blood disorder, in which red blood cell count is decreased to below normal level and it affects the transport of oxygen to body tissue. In this condition the body gets low oxygen supply and leads to oxidative stress. Anemia can be caused by blood loss, destruction of red blood cells or less synthesis of red blood cells. The main symptoms of anemia include pale face, exhaustion, and difficulty in breathing, dizziness or a fast heartbeat. If we haven’t diagnosis the anemia in time then it may leads to death of that individual. The treatments used for the diagnoses of anemia are, one should maintain the normal iron level by taking the iron supplements to overcome the anemic condition. In blood loss condition, transfusion of healthy blood to the patient will helps to overcome the anemia. To increase the productions of RBC, one can use the medications like vitamin B and C and Erythropoiesis-Stimulating Agents are used.

Anemia and Its Application in Current Research World

Hypokalemic intermittent loss of motion is an uncommon, autosomal prevailing channelopathy described by muscle shortcoming or loss of motion with a coordinating fall in potassium levels in the blood. In people with this transformation, assaults regularly start in pre-adulthood and most usually happen on arousing or after rest or rest taking after strenuous work out, high starch dinners, suppers with high sodium content, sudden changes in temperature, and even energy, clamor, blazing lights and instigated by cool temperatures. Shortcoming might be mellow and constrained to certain muscle gatherings, or more extreme full-body loss of motion. Licorice concentrates and its key segment, glycyrrhizin, have broad use in nourishments, tobacco items, and snuff, and in customary and home grown prescription. Licorice remove (square, powder, or fluid) might be connected to cigarette tobacco at levels of around 1-4% to upgrade and fit the flavor attributes of smoke, enhance dampness holding qualities of tobacco, and go about as a surface-dynamic operator for fixing application.

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A Strange reason for Hypokalemic loss of Motion: Ceaseless Licorice Ingestion

Although not so common, we do come across some cases of pseudo hypertension in the elderly population. A few years ago we had tried focusing attention of the medical fraternity to this condition as well [4]. Here in this condition that is attributed to arteriosclerosis; blood pressure may be apparently high and could prompt unwarranted excessive treatment due to falsely high blood pressures levels [4].

Hypertension and the Aged

Eagle's syndrome, also known as elongated styloid process, is a condition that may be the source of craniofacial and cervical pain. It is infrequently reported but is probably more common than generally considered. Diagnosis is confirmed through clinical symptoms, radiological findings, and physical examinations. In this paper a case of ES exhibiting unilateral symptoms with bilateral elongation of styloid process is reported and the literature is reviewed.

Bilateral elongated styloid process-a case report

Universally it is almost a common knowledge that the elderly is not interested in prolongation of their life. Perhaps the ones who are ambulatory and are able to perform their activities of daily living are not looking forward for a longdrawn- out life, but a life where they feel comfortable without being dependent on anyone. Perhaps most of their time may be spent in contemplating and taking measures on how not to fall ill, and continue being independent.

/pdf/fresh-approach-for-geriatric-medical-care-1tbe2z7386.pdf

Fresh Approach for Geriatric Medical Care

After “Innovative medical techniques showcased at international conferences”, this is second book by Hon' National Professor, Dr. Rajesh Chauhan and his co-workers. Meant as a curtain raiser only, this book brings out newer perspectives and innovative techniques of management of 25 common chronic diseases, which are totally painless, non-surgical, and non-invasive, and can usher in some refreshing changes that can be highly beneficial to the patients all around the world. These new techniques can help cut down on the number of medicines, their doses and the frequency of use in conditions like primary hypertension, T2 diabetes, presbycusis, BPH, ‘nose job’, DNS, haemorrhoids, external hernias, goiter, hoarseness, anisocoria, gynaecomastia, knee arthritis, spondylosis & stenosis of spine, management of such tricky conditions like coronary micro vascular disease, pacing of heart, sleep apnea & snoring, management of gall bladder and ureteric stones, & non-invasive restoration of coronary & carotid circulation, rejuvenation and easy management of multimorbidities. Certainly much more research is necessary to make all these techniques viable, predictable and totally safe.

Innovative techniques for treating 25 common chronic human diseases

Geriatric population is increasing by the day, and what’s more worrisome are the accompanying morbidities with aging. Multimorbidity seems to be a common presentation in the aged which usually leads to polypharmacy, and that again is a growing concern. As we had said many years ago, it’s not that the aged are looking forward to increased longitivity [1]. They are probably more interested to remain fit enough so as to carry on with their daily chores, as was opined by us [1]. Since one size will never fit all, therefore, based on the multi-morbidities an individually tailored approach may perhaps be more helpful. With the decline of the bodily functions and physiology as we age, there can be so many different medical and physical disabilities. There can be all sorts of combinations of problems, some apparent and many unapparent, which will require all the skills and expertise from a Geriatrician or from the treating physician. May be a revisit and a fresh look at all the problems from head to toe might help in pruning down the list of diagnosis, which in turn could also help to curtail inadvertent polypharmacy.

Rajesh Chauhan

Papers

Hypertension and the Aged

Bilateral elongated styloid process-a case report

Fresh Approach for Geriatric Medical Care

Innovative techniques for treating 25 common chronic human diseases

Perhaps its Time to Move on to Individually Tailored and FocusedTreatment in the Aged Population