R
Rajni Chibbar
Researcher at University of Saskatchewan
Publications - 66
Citations - 2018
Rajni Chibbar is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Cytotoxic T cell & CTL*. The author has an hindex of 24, co-authored 63 publications receiving 1785 citations. Previous affiliations of Rajni Chibbar include University of Alberta & Royal University Hospital.
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Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition.
TL;DR: The hypothesis of a paracrine system involving OT and sex steroids within intrauterine tissues wherein significant changes could occur without being reflected in the maternal circulation could rationalize a long-sought role for oxytocin in the physiology of human labor.
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Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen.
Nael Shoman,Shannon Klassen,Andrew McFadden,Miķelis G. Bickis,Emina Torlakovic,Rajni Chibbar +5 more
TL;DR: A strong association between downregulation of PTEN expression in ER-α-positive tumors and failure to tamoxifen treatment was showed.
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Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8(+) CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70.
Yufeng Xie,Ou Bai,Haifeng Zhang,Jinying Yuan,Sam Zong,Rajni Chibbar,Karen Slattery,Mabood Qureshi,Yangdou Wei,Yulin Deng,Jim Xiang +10 more
TL;DR: It is demonstrated that EXOHSP are able to stimulate type 1 CD4+ helper T (Th1) cell responses, and more efficient P1A‐specific CD8+ cytotoxic T lymphocyte (CTL) responses and antitumour immunity than EXOHS.
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Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity
Yufeng Xie,Haifeng Zhang,Wei Li,Yulin Deng,Manjunatha Ankathatti Munegowda,Rajni Chibbar,Mabood Qureshi,Jim Xiang +7 more
TL;DR: The data indicate that Ag-specific CD8+ T cells can modulate immune responses via T cell-released EXOs, and T cell EXOs may be useful for treatment of autoimmune diseases.
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CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity.
TL;DR: The data indicate that antigen-specific T-cell EXO may serve as a new type of immunosuppressive reagent for use in transplant rejection and treatment of autoimmune diseases.