R
Rajnikant Dixit
Researcher at National Institute of Malaria Research
Publications - 69
Citations - 1400
Rajnikant Dixit is an academic researcher from National Institute of Malaria Research. The author has contributed to research in topics: Anopheles stephensi & Proteases. The author has an hindex of 14, co-authored 60 publications receiving 1139 citations. Previous affiliations of Rajnikant Dixit include Maharshi Dayanand University & National Institutes of Health.
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Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes.
Janneth Rodrigues,Fábio André Brayner,Luiz Carlos Alves,Rajnikant Dixit,Carolina Barillas-Mury +4 more
TL;DR: The immune system of mosquitoes is primed early-on when the malaria parasite (Plasmodium spp.) first crosses the mosquito gut epithelial barrier, and a substantial increase in a single type of hemocyte (macrophage-like insect immune cells) is implicated in long-lived antiplasmodial immunity.
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Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets.
TL;DR: This review specifically highlights the modes of activation (processing) of papain family enzymes, which involve auto-activation, trans-activation and also clarifies the future aspects of targeting PPIs to prevent the activation of cysteine proteases.
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The STAT Pathway Mediates Late-Phase Immunity against Plasmodium in the Mosquito Anopheles gambiae
Lalita Gupta,Alvaro Molina-Cruz,Sanjeev Kumar,Janneth Rodrigues,Rajnikant Dixit,Rodolfo E. Zamora,Carolina Barillas-Mury +6 more
TL;DR: The AgSTAT-A pathway mediates a late-phase antiplasmodial response that reduces oocyst survival in A. gambiae, and silencing of SOCS, a STAT suppressor, has the opposite effect, reducing Plasmodium infection by increasing NOS expression.
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Salivary glands harbor more diverse microbial communities than gut in Anopheles culicifacies.
Punita Sharma,Punita Sharma,S.K. Sharma,Rakesh Maurya,Tanwee Das De,Tina Thomas,S. Lata,Namita Singh,Kailash C. Pandey,Neena Valecha,Rajnikant Dixit +10 more
TL;DR: The salivary gland microbial community structure is more diverse than gut of the mosquito, probably due to differential feeding associated engagements such as food acquisition, ingestion and digestion processes.
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Structure-function of falcipains: malarial cysteine proteases.
TL;DR: Structural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain that provide structural insight to facilitate the design or modification of effective drug treatment against malaria.