Ramesa Shafi Bhat

TL;DR: There is a need to identify objective biological markers associated with diagnosis or clinical severity of the disorder and the search for high-performing bio-analytes to diagnose and follow-up ASD development is still a major target in medicine.

TL;DR: In this paper, the role of altered gut microbiota observed frequently in autistic patients, and the mechanisms through which such alterations may trigger leaky gut was discussed, and diagnostic and therapeutic value of intestinal proteins and bacterial derived compounds as new possible biomarkers, as well as potential therapeutic targets were discussed.

TL;DR: Both bee pollen and propolis were effective in ameliorating the neurotoxic effects of PPA demonstrating non-significant changes of IL-6 and IL-10 when compared to control healthy hamsters.

TL;DR: The low dose and the short duration of N-acetyl-cysteine treatment tested showed much more protective rather than therapeutic effects on PPA-induced neurotoxicity in rats, as there was a remarkable amelioration in the impaired biochemical parameters representing neurochemical, inflammatory, detoxification and DNA damage processes.

TL;DR: It is concluded that impairment at various steps of the lipid metabolic pathways may contribute to the development of autism; however, supplementation with ω-3 and vitamin B12 can result in a positive therapeutic effect.