R
Randy Ira Hecht
Researcher at Amgen
Publications - 47
Citations - 7813
Randy Ira Hecht is an academic researcher from Amgen. The author has contributed to research in topics: Nucleic acid & Mutant. The author has an hindex of 22, co-authored 47 publications receiving 7441 citations. Previous affiliations of Randy Ira Hecht include Protein Sciences.
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Journal ArticleDOI
Effects of the obese gene product on body weight regulation in ob/ob mice
Mary Ann Pelleymounter,Mary Jane Cullen,Mary Beth Baker,Randy Ira Hecht,Dwight Winters,Thomas C. Boone,Frank H. Collins +6 more
TL;DR: The data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.
Journal ArticleDOI
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu,David Lloyd,Clarence Hale,Shanaka Stanislaus,Michelle Chen,Glenn Sivits,Steven Vonderfecht,Randy Ira Hecht,Yue-Sheng Li,Richard A. Lindberg,Jin-Long Chen,Dae Young Jung,Zhiyou Zhang,Hwi Jin Ko,Jason K. Kim,Murielle M. Véniant +15 more
TL;DR: FGF21 corrects multiple metabolic disorders in DIO mice and has the potential to become a powerful therapeutic to treat hepatic steatosis, obesity, and type 2 diabetes.
Journal ArticleDOI
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Jing Xu,Shanaka Stanislaus,Narumol Chinookoswong,Yvonne Y. Lau,Todd Hager,Jennifer Patel,Hongfei Ge,Jen Weiszmann,Shu-Chen Lu,Melissa Graham,Jim Busby,Randy Ira Hecht,Yue-Sheng Li,Yang Li,Richard A. Lindberg,Murielle M. Véniant +15 more
TL;DR: The acute glucose-lowering and insulin-sensitizing effects of FGF21 are potentially associated with its metabolic actions in liver and adipose tissues.
Journal ArticleDOI
FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation
Xinle Wu,Hongfei Ge,Bryan Lemon,Steven Vonderfecht,Jennifer Weiszmann,Randy Ira Hecht,Jamila Gupte,Todd Hager,Zhulun Wang,Richard A. Lindberg,Yang Li +10 more
TL;DR: It is determined that amino acids residues 38–42 of FGF19 are sufficient to confer bothFGFR4 activation and increased hepatocyte proliferation in vivo to FGF21, suggesting that activation of FGFR4 is the mechanism whereby FGF 19 can increase hepatocytes proliferation and induce hepatocellular carcinoma formation.
Journal ArticleDOI
FGF21 N- and C-termini play different roles in receptor interaction and activation
Junming Yie,Randy Ira Hecht,Jennifer Patel,Jennitte Stevens,Wei Wang,Nessa Hawkins,Shirley Steavenson,Steve Smith,Dwight Winters,Seth Fisher,Ling Cai,Ed Belouski,Ching Chen,Mark Leo Michaels,Yue-Sheng Li,Richard A. Lindberg,Minghan Wang,Murielle M. Véniant,Jing Xu +18 more
TL;DR: FGF21 binds (MI:0407) to β‐Klotho (uniprotkb: Q86Z14) by surface plasmon resonance (MI):0107 and FGF21 ( uniprot kb: Q9NSA1) binds ( MI):0407.