R
Răzvan C. Cioc
Researcher at VU University Amsterdam
Publications - 18
Citations - 1243
Răzvan C. Cioc is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Isocyanide & Enantioselective synthesis. The author has an hindex of 10, co-authored 16 publications receiving 984 citations.
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Multicomponent reactions: advanced tools for sustainable organic synthesis
TL;DR: In this article, the utility of multicomponent reactions as methods for green synthesis is highlighted and the practical value of these type of reactions for meeting many of the criteria set by the green chemistry philosophy.
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Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium‐Catalyzed Aerobic Oxidative Isocyanide Insertion
Tjoestil Vlaar,Răzvan C. Cioc,Pieter Mampuys,Bert U. W. Maes,Romano V. A. Orru,Eelco Ruijter +5 more
TL;DR: The utility of this highly sustainable method is demonstrated by a formal synthesis of the antihistamines astemizole and norastemizole, and a diverse array of medicinally relevant N heterocycles.
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Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles.
Jordy M. Saya,Barry Oppelaar,Răzvan C. Cioc,Gydo van der Heijden,Christophe M. L. Vande Velde,Romano V. A. Orru,Eelco Ruijter +6 more
TL;DR: A highly diastereoselective interrupted Ugi reaction is reported to construct a broad range of structurally congested and stereochemically complex spiroindolines from tryptamine-derived isocyanides to give polycyclic products in moderate to excellent yields.
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Biocatalytic access to nonracemic γ-oxo esters via stereoselective reduction using ene-reductases
Nikolaus G. Turrini,Răzvan C. Cioc,Daan J. H. van der Niet,Eelco Ruijter,Romano V. A. Orru,Mélanie Hall,Kurt Faber +6 more
TL;DR: The asymmetric bioreduction of α,β-unsaturated γ-keto esters using ene-reductases from the Old Yellow Enzyme family proceeds with excellent stereoselectivity and high conversion levels, covering a broad range of acyclic and cyclic derivatives.
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Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions
TL;DR: This reagent can be employed as a cyanide source in the Strecker reaction and as convertible isocyanide in the preparation of N-acyl amino acids by Ugi 4CR/detritylation and free imidazo[1,2-a]pyridin-3-amines by a Groebke-Blackburn-Bienaymé 3CR condensation/deprotection protocol.