René Handrick

TL;DR: This contribution provides a summary of the biochemical and molecular biological characteristics of e-PHA depolymerases and focuses on the intracellular mobilization of storage PHA by intracesllular PHA depolemerases (i-P HA depolyMERases) of PHA-accumulating bacteria.

TL;DR: This review provides a comprehensive summary of the most fundamental achievements in CHO cell engineering over the past three decades and discusses the potential of novel and innovative methodologies that might contribute to further enhancement of existing CHO based production platforms for biopharmaceutical manufacturing in the future.

TL;DR: Celecoxib induces apoptosis via a novel apoptosome‐dependent but Bcl‐2‐independent mitochondrial pathway through the induction of apoptosis upon treatment with Celecoxib was tested in Jurkat T‐ and BJAB B‐lymphoma cell lines with defects in either pathway.

TL;DR: A novel type of hydrolase was purified from culture fluid of Paucimonas (formerlyPseudomonas) lemoignei and revealed an unusual substrate specificity of the purified enzyme for amorphous poly((R)-3-hydroxyalkanoates) (PHA), which has the unique property to recognize the physical state of the polymeric substrate by discrimination between amorphously PHA and denatured, partially crystalline PHA.

TL;DR: Native PHB granules isolated from chromosomal knockout mutants of an intracellular PHB (i-PHB) depolymerase gene of R. eutropha H16 and HF210 showed a reduced but not completely eliminated activity of 3HB release and indicated the presence of i- PHB depolyMERase isoenzymes.