This paper presents a review of the ways in which optimal control theory interacts with cancer chemotherapy. There are three broad areas of investigation. One involves miscellaneous growth kinetic models, the second involves cell cycle models, and the third is a classification of "other models." Both normal and tumor cell populations are included in a number of the models. The concepts of deterministic optimal control theory are applied to each model in such a way as to present a cohesive picture. There are applications to both experimental and clinical tumors. Suggestions for designing better chemotherapy strategies are presented.

Role of optimal control theory in cancer chemotherapy.

An integrated visual defect detection and classification system. The invention includes adaptive defect detection and image labeling, defect feature measures, and a knowledge based inference shell/engine for classification based on fuzzy logic. The combination of these elements comprises a method and system for providing detection and analysis of product defects in many application domains, such as semiconductor and electronic packaging manufacturing.

Automated defect classification system

Steel is the material of choice for a large number and very diverse industrial applications. Surface qualities along with other properties are the most important quality parameters, particularly for flat-rolled steel products. Traditional manual surface inspection procedures are awfully inadequate to ensure guaranteed quality-free surface. To ensure stringent requirements of customers, automated vision-based steel surface inspection techniques have been found to be very effective and popular during the last two decades. Considering its importance, this paper attempts to make the first formal review of state-of-art of vision-based defect detection and classification of steel surfaces as they are produced from steel mills. It is observed that majority of research work has been undertaken for cold steel strip surfaces which is most sensitive to customers' requirements. Work on surface defect detection of hot strips and bars/rods has also shown signs of increase during the last 10 years. The review covers overall aspects of automatic steel surface defect detection and classification systems using vision-based techniques. Attentions have also been drawn to reported success rates along with issues related to real-time operational aspects.

https://link.springer.com/content/pdf/10.1186%2F1687-5281-2014-50.pdf

Review of vision-based steel surface inspection systems

Automated computer-vision-based defect detection has received much attention with the increasing surface quality assurance demands for the industrial manufacturing of flat steels. This article attempts to present a comprehensive survey on surface defect detection technologies by reviewing about 120 publications over the last two decades for three typical flat steel products of con-casting slabs and hot- and cold-rolled steel strips. According to the nature of algorithms as well as image features, the existing methodologies are categorized into four groups: statistical, spectral, model-based, and machine learning. These works are summarized in this review to enable easy referral to suitable methods for diverse application scenarios in steel mills. Realization recommendations and future research trends are also addressed at an abstract level.

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Automated Visual Defect Detection for Flat Steel Surface: A Survey

An improved classification system for classifying characteristics of an article into classes of characteristics based on features associated with the characteristics. The system includes a first rule-based classifier that provides rules that embody requirements of selected features so as to together define selected classes. These rules are applied to measured features of an article characteristic to assign one of the selected classes to that characteristic, should the article characteristic meet the feature requirements of one of the selected classes. The system also includes a trainable classifier configured based on a training set of preclassified characteristics, with the trainable classifier connected so as to accept from the first rule-based classifier an article characteristic not classified by the rule based classifier. The trainable classifier assigns one of the training set classes to the unclassified characteristic, should the trainable classifier configuration associate that characteristic with one of the training set classes. A second rule-based classifier can be connected so as to accept classified characteristics from the trainable classifier for making refinement classifications, and a third rule-based classifier can be connected so as to accept unclassified characteristics from the trainable classifier for making classification based on selected classes.

Automatic classifier for real time inspection and classification

A method and apparatus relating to the real time automatic detection and classification of characteristic type surface imperfections occurring on the surfaces of material of interest such as moving hot metal slabs produced by a continuous steel caster. A data camera transversely scans continuous lines of such a surface to sense light intensities of scanned pixels and generates corresponding voltage values. The voltage values are converted to corresponding digital values to form a digital image of the surface which is subsequently processed to form an edge-enhanced image having scan lines characterized by intervals corresponding to the edges of the image. The edge-enhanced image is thresholded to segment out the edges and objects formed by the edges are segmented out by interval matching and bin tracking. Features of the objects are derived and such features are utilized to classify the objects into characteristic type surface imperfections.

Real time automated inspection

This paper describes an inspection system designed to automatically detect and classify surface imperfections occurring on continuously cast hot steel slabs in a steel mill. The need to perform inspection at real-time throughput rates of 546 Kpixels/s using off-the-shelf components has led to the development of a unique architecture and algorithm set. The segmentation operations are done in a high-speed array processor front end. The imperfection classification is done in a mini-computer which uses statistical as well as syntactic/semantic classification techniques. The inspection system is currently undergoing evaluation in a steel mill.

A Real-Time Automated Visual Inspection System for Hot Steel Slabs

A method and apparatus relating to the real time automatic detection and classification of characteristic type surface imperfections occurring on the surfaces of material of interest such as moving hot metal slabs (26) produced by a continuous steel caster. A data camera (34) transversely scans continuous lines of such a surface to sense light Intensities of scanned pixels and generates corresponding voltage values. The voltage values are converted to corresponding digital values to form a digital image of the surface which is subsequently processed to form an edge-enhanced image having scan lines characterized by intervals corresponding to the edges of the image. The edge-enhanced image is thresholded to segment out the edges and objects formed by the edges are segmented out by interval matching and bin tracking. Features of the objects are derived and such features are utilized to classify the objects into characteristic type surface imperfections (Fig. 2).

Method and apparatus for detection and classification of surface imperfections

Various types of mathematical models, such as partial differential equations, ordinary differential equations and difference equations, are available in the literature to describe the kinetics of cell proliferation, and different studies of cell kinetic phenomena have been conducted using these models. This paper discusses the equivalence between the different models identifying the conditions and approximations under which one type of models may be derived from another. Such an equivalence study is highly useful for an integration of the diverse results that have been obtained using different models in order to gain a more complete understanding of cell kinetic phenomena.

Richard A. Fundakowski

Papers

Real time automated inspection

A Real-Time Automated Visual Inspection System for Hot Steel Slabs

Method and apparatus for detection and classification of surface imperfections

On the Equivalence of Mathematical Models For Cell Proliferation Kinetics

Periodic optimization of a class of bilinear systems with application to control of compartmental structures arising in cancer therapy