抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Ecological changes in the phenology and distribution of plants and animals are occurring in all well-studied marine, freshwater, and terrestrial groups These observed changes are heavily biased in the directions predicted from global warming and have been linked to local or regional climate change through correlations between climate and biological variation, field and laboratory experiments, and physiological research Range-restricted species, particularly polar and mountaintop species, show severe range contractions and have been the first groups in which entire species have gone extinct due to recent climate change Tropical coral reefs and amphibians have been most negatively affected Predator-prey and plant-insect interactions have been disrupted when interacting species have responded differently to warming Evolutionary adaptations to warmer conditions have occurred in the interiors of species’ ranges, and resource use and dispersal have evolved rapidly at expanding range margins Observed genetic shifts modulate local effects of climate change, but there is little evidence that they will mitigate negative effects at the species level

https://www.fws.gov/southwest/es/documents/R2ES/LitCited/LPC_2012/Parmesan_2006.pdf

Ecological and Evolutionary Responses to Recent Climate Change

Greenland ice-core data have revealed large decadal climate variations over the North Atlantic that can be related to a major source of low-frequency variability, the North Atlantic Oscillation. Over the past decade, the Oscillation has remained in one extreme phase during the winters, contributing significantly to the recent wintertime warmth across Europe and to cold conditions in the northwest Atlantic. An evaluation of the atmospheric moisture budget reveals coherent large-scale changes since 1980 that are linked to recent dry conditions over southern Europe and the Mediterranean, whereas northern Europe and parts of Scandinavia have generally experienced wetter than normal conditions.

http://science.sciencemag.org/content/sci/269/5224/676.full.pdf

Decadal Trends in the North Atlantic Oscillation: Regional Temperatures and Precipitation

[1] We present a 53-Myr stack (the “LR04” stack) of benthic δ18O records from 57 globally distributed sites aligned by an automated graphic correlation algorithm This is the first benthic δ18O stack composed of more than three records to extend beyond 850 ka, and we use its improved signal quality to identify 24 new marine isotope stages in the early Pliocene We also present a new LR04 age model for the Pliocene-Pleistocene derived from tuning the δ18O stack to a simple ice model based on 21 June insolation at 65°N Stacked sedimentation rates provide additional age model constraints to prevent overtuning Despite a conservative tuning strategy, the LR04 benthic stack exhibits significant coherency with insolation in the obliquity band throughout the entire 53 Myr and in the precession band for more than half of the record The LR04 stack contains significantly more variance in benthic δ18O than previously published stacks of the late Pleistocene as the result of higher-resolution records, a better alignment technique, and a greater percentage of records from the Atlantic Finally, the relative phases of the stack's 41- and 23-kyr components suggest that the precession component of δ18O from 27–16 Ma is primarily a deep-water temperature signal and that the phase of δ18O precession response changed suddenly at 16 Ma

/pdf/a-pliocene-pleistocene-stack-of-57-globally-distributed-n5iphe7mt2.pdf

A Pliocene-Pleistocene stack of 57 globally distributed benthic δ18O records

Anthropogenic pressures on the Earth System have reached a scale where abrupt global environmental change can no longer be excluded. We propose a new approach to global sustainability in which we define planetary boundaries within which we expect that humanity can operate safely. Transgressing one or more planetary boundaries may be deleterious or even catastrophic due to the risk of crossing thresholds that will trigger non-linear, abrupt environmental change within continental- to planetary-scale systems. We have identified nine planetary boundaries and, drawing upon current scientific understanding, we propose quantifications for seven of them. These seven are climate change (CO2 concentration in the atmosphere <350 ppm and/or a maximum change of +1 W m-2 in radiative forcing); ocean acidification (mean surface seawater saturation state with respect to aragonite ≥ 80% of pre-industrial levels); stratospheric ozone (<5% reduction in O3 concentration from pre-industrial level of 290 Dobson Units); biogeochemical nitrogen (N) cycle (limit industrial and agricultural fixation of N2 to 35 Tg N yr-1) and phosphorus (P) cycle (annual P inflow to oceans not to exceed 10 times the natural background weathering of P); global freshwater use (<4000 km3 yr-1 of consumptive use of runoff resources); land system change (<15% of the ice-free land surface under cropland); and the rate at which biological diversity is lost (annual rate of <10 extinctions per million species). The two additional planetary boundaries for which we have not yet been able to determine a boundary level are chemical pollution and atmospheric aerosol loading. We estimate that humanity has already transgressed three planetary boundaries: for climate change, rate of biodiversity loss, and changes to the global nitrogen cycle. Planetary boundaries are interdependent, because transgressing one may both shift the position of other boundaries or cause them to be transgressed. The social impacts of transgressing boundaries will be a function of the social-ecological resilience of the affected societies. Our proposed boundaries are rough, first estimates only, surrounded by large uncertainties and knowledge gaps. Filling these gaps will require major advancements in Earth System and resilience science. The proposed concept of "planetary boundaries" lays the groundwork for shifting our approach to governance and management, away from the essentially sectoral analyses of limits to growth aimed at minimizing negative externalities, toward the estimation of the safe space for human development. Planetary boundaries define, as it were, the boundaries of the "planetary playing field" for humanity if we want to be sure of avoiding major human-induced environmental change on a global scale.

/pdf/planetary-boundaries-exploring-the-safe-operating-space-for-ir5ysgjg96.pdf

Planetary boundaries: Exploring the safe operating space for humanity

Rapid retreat of the Larsen A and B ice shelves has provided important clues about the ice shelf destabilization processes. The Larsen C Ice Shelf, the largest remaining ice shelf on the Antarctic Peninsula, may also be vulnerable to future collapse in a warming climate. Here, we utilize multisource satellite images collected over 1963–2020 to derive multidecadal time series of ice front, flow velocities, and critical rift features over Larsen C, with the aim of understanding the controls on its retreat. We complement these observations with modeling experiments using the Ice‐sheet and Sea‐level System Model to examine how front geometry conditions and mechanical weakening due to rifts affect ice shelf dynamics. Over the past six decades, Larsen C lost over 20% of its area, dominated by rift‐induced tabular iceberg calving. The Bawden Ice Rise and Gipps Ice Rise are critical areas for rift formation, through their impact on the longitudinal deviatoric stress field. Mechanical weakening around Gipps Ice Rise is found to be an important control on localized flow acceleration and the propagation of two rifts that caused a major calving event in 2017. Capturing the time‐varying effects of rifts on ice rigidity in ice shelf models is essential for making realistic predictions of ice shelf flow dynamics and instability. In the context of the Larsen A and Larsen B collapses, we infer a chronology of destabilization processes for embayment‐confined ice shelves, which provides a useful framework for understanding the historical and future destabilization of Antarctic ice shelves.

Controls on Larsen C Ice Shelf Retreat From a 60‐Year Satellite Data Record

Amplitude analysis of active source seismic data from the grounding zone of Whillans Ice Stream

Seismic imaging of former grounding lines beneath Whillans Ice Stream, West Antarctica

We report here on some of the results of our first two seasons work along the Siple Coast. These results are all preliminary in nature and could be modified substantially with further analysis. Furthermore, we have selected from a much larger body of data only a few points that we believe will be of interest to this workshop.

Richard B. Alley

Papers

Controls on Larsen C Ice Shelf Retreat From a 60‐Year Satellite Data Record

Amplitude analysis of active source seismic data from the grounding zone of Whillans Ice Stream

Seismic imaging of former grounding lines beneath Whillans Ice Stream, West Antarctica

A Few Preliminary Results from the Glaciogeophysical Survey of the Interior Ross Embayment (GSIRE)

Laboratory Study of Till Rheology