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Richard C. Storr
Researcher at University of Liverpool
Publications - 149
Citations - 1896
Richard C. Storr is an academic researcher from University of Liverpool. The author has contributed to research in topics: Cycloaddition & Flash vacuum pyrolysis. The author has an hindex of 24, co-authored 149 publications receiving 1836 citations. Previous affiliations of Richard C. Storr include Liverpool School of Tropical Medicine & University of Manchester.
Papers
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Journal ArticleDOI
Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials
Paul M. O'Neill,Amira Mukhtar,Paul A. Stocks,Laura E. Randle,Stephen Hindley,Stephen A. Ward,Richard C. Storr,Jamie F. Bickley,Ian A. O'Neil,James L. Maggs,Ruth H Hughes,P. A. Winstanley,Patrick G. Bray,B. Kevin Park +13 more
TL;DR: Isoquine (ISQ1 (3a) represents a new second generation lead worthy of further investigation as a cost-effective and potentially safer alternative to amodiaquine, and was selected for in vivo antimalarial assessment.
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Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
Stephen Hindley,Stephen A. Ward,Richard C. Storr,Natalie L. Searle,Patrick G. Bray,B. Kevin Park,Jill Davies,Paul M. O'Neill +7 more
TL;DR: The incorporation of amino functionality into target artemisinin analogues was hoped to prepare a new series of analogues that, by virtue of increased accumulation into the ferrous-rich vacuole, would display enhanced antimalarial potency.
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Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
Paul M. O'Neill,David J. Willock,S R Hawley,Patrick G. Bray,Richard C. Storr,Stephen A. Ward,Brian Kevin Park +6 more
TL;DR: A novel more efficient synthetic route to tebuquine analogues is developed which involves the use of a palladium-catalyzed Suzuki reaction to introduce the 4-chlorophenyl moiety into the4-hydroxyaniline side chain, which had the most favorable interaction energy in both the in vacuo and solvent-based simulation studies.
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The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.
TL;DR: F fluorine substitution at the 2',6'-positions and replacement of the 4'-hydroxyl of amodiaquine with fluorine produces analogues that maintain antimalarial efficacy in vitro and are more resistant to oxidation and hence less likely to form toxic quinone imine metabolites in vivo.
Journal ArticleDOI
Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether
Paul M. O'Neill,Natalie L. Searle,Kan Kw,Richard C. Storr,James L. Maggs,Stephen A. Ward,Kaylene J. Raynes,B.K. Park +7 more
TL;DR: Ten novel, second-generation, fluorinated ether and ester analogues of the potent first-generation analogues artemether and arteether have been designed and synthesized and demonstrate high antimalarial potency in vitro against the chloroquine-sensitive HB3 and -resistant K1 strains of Plasmodium falciparum.