R
Richard F. Hector
Researcher at University of California, San Francisco
Publications - 27
Citations - 1257
Richard F. Hector is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Coccidioides immitis & Itraconazole. The author has an hindex of 18, co-authored 27 publications receiving 1186 citations. Previous affiliations of Richard F. Hector include University of California, Davis.
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Journal ArticleDOI
Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis.
TL;DR: Results of limited toxicology tests suggest that nikkomycin Z was well tolerated at the dosages employed, and that absorption after oral administration was sufficiently slow to allow inhibitory levels to persist for more than 2 h.
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Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human
TL;DR: Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient, and required 100 and 50 μg/ml, respectively, for complete inhibition at 48 h.
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Coccidioidomycosis--a fungal disease of the Americas.
TL;DR: Coccidioidomycosis was first recognized as a serious disease over 100 years ago, but the disease remains an enigma and often goes undiagnosed, even in endemic areas.
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The public health impact of coccidioidomycosis in Arizona and California.
Richard F. Hector,George W. Rutherford,Clarisse A. Tsang,Laura M. Erhart,Orion McCotter,Shoana Anderson,Kenneth Komatsu,Farzaneh Tabnak,Duc J. Vugia,Ying Xue Yang,John N. Galgiani +10 more
TL;DR: The numbers of reported cases of coccidioidomycosis in Arizona and California have risen dramatically over the past decade, with a 97.8% and 91.1% increase in incidence rates from 2001 to 2006 in the two states, respectively.
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Synergy, Pharmacodynamics, and Time-Sequenced Ultrastructural Changes of the Interaction between Nikkomycin Z and the Echinocandin FK463 against Aspergillus fumigatus
TL;DR: These two cell wall-targeted antifungal agents, FK and NZ, showed marked time-dependent in vitro synergistic activity against A. fumigatus, with marked transformation of hyphae to blastospore-like structures, in the presence of FK plus NZ, while fungi treated with a single drug showed partial recovery at 24 h.