Richard Fitzpatrick

TL;DR: A dataset on 500 lactations explored the relationships between metabolic traits measured before and after calving with fertility and showed that longer calving to conception intervals were associated with altered profiles of IGF-I, urea and body condition score.

TL;DR: Evidence is provided that cows in SNEB were still undergoing an active uterine inflammatory response 2 wk postpartum, whereas MNEB cows had more fully recovered from their energy deficit, with their endometrium reaching a more advanced stage of repair.

TL;DR: It is demonstrated that SNEB affects hepatic synthesis of IGF-I, and other components known to modulate the bioavailability and stability of circulating IGF- I, and that SN EB affects hepatics synthesis of mRNA for IGF-II and receptors for insulin (A/B) and glucocorticoid (alpha) was unaffected by EB.

TL;DR: The results suggest that cows in SNEB experience alterations to the IGF and insulin signalling pathways in the postpartum endometrium, which may affect the rate of tissue repair with a possible negative impact on subsequent fertility.

TL;DR: Results indicate that, in addition to low circulating IGF-I after calving, NEB may also influence IGF availability in the oviduct indirectly through changes in specific IGFBP expression, contributing to the high rates of embryonic mortality in dairy cows.