R
Richard G. Moran
Researcher at University of Southern California
Publications - 33
Citations - 2600
Richard G. Moran is an academic researcher from University of Southern California. The author has contributed to research in topics: Thymidylate synthase & Folinic acid. The author has an hindex of 22, co-authored 33 publications receiving 2519 citations. Previous affiliations of Richard G. Moran include VCU Medical Center & Children's Hospital Los Angeles.
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Journal ArticleDOI
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
TL;DR: The presence of 5-hydroxymethylcytosine (5hmC) as well as 5mC in mammalian mtDNA is reported, suggesting that previous studies underestimated the level of cytosine modification in this genome.
Book ChapterDOI
Fluorinated Pyrimidines and Their Nucleosides
TL;DR: A review of the major pharmacological and biochemical effects of the fluorinated pyrimidine nucleosides can be found in this paper, where the authors focus mainly on key references that are germane to the topics being described.
Journal Article
In Vivo Kinetics of Thymidylate Synthetase Inhibition in 5-Fluorouracil-sensitive and -resistant Murine Colon Adenocarcinomas
C. Paul Spears,Antranik H. Shahinian,Richard G. Moran,Charles Heidelberger,Thomas H. Corbett +4 more
TL;DR: Levels of free TS in the tumor after 5-FUra treatment are predictive of chemotherapeutic response in these murine models of human colonic adenocarcinoma, and could not be explained by the small differences among the tumors in total perchloric acid-soluble metabolites of 5-UFra or drug incorporation into RNA.
Journal ArticleDOI
A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase
Edward C. Taylor,Dietmar G Kuhnt,Chuan Shih,Sharon M. Rinzel,Gerald B. Grindey,Julio C. Barredo,Mehrdad Jannatipour,Richard G. Moran +7 more
TL;DR: L-glutamic acid (15), prepared in five steps from 2-pivaloyl-7-deazaguanine, has been found to be an antitumor agent with its primary site of action at thymidylate synthase rather than purine synthesis.
Journal Article
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
TL;DR: F folinic acid stabilizes the effects of the fluoropyrimidines on thymidylate synthase of both mouse and human leukemic cell populations and that this enhancement is reflected in both inhibition of the growth of and the lethality to these cells.