R
Richard Kirsh
Researcher at GlaxoSmithKline
Publications - 22
Citations - 1112
Richard Kirsh is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Liposome & In vivo. The author has an hindex of 12, co-authored 22 publications receiving 1102 citations. Previous affiliations of Richard Kirsh include Smith, Kline & French.
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Journal Article
Analysis of the Fate of Systemically Administered Liposomes and Implications for Their Use in Drug Delivery
TL;DR: It is concluded that free liposomes are unable to extravasate to reach the alveoli for subsequent engulfment by alveolar macrophages and the feasibility of usingliposomes to "target" drugs to cells in extravascular tissues is called into question.
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Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.
Timothy K. Hart,Richard Kirsh,Harma Ellens,Raymond W. Sweet,Dennis M. Lambert,Stephen R. Petteway,Jeffry J. Leary,Peter J. Bugelski +7 more
TL;DR: The results suggest that soluble CD4 constructs may inactivate HIV by inducing the release of gp120, and it is proposed that HIV envelope-mediated fusion is initiated following rearrangement and/or dissociation ofgp120 from the gp120-gp41 complex upon binding to cellular CD4, thus exposing the fusion domain of gp41.
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Site–Specific (Targeted) Drug Delivery in Cancer Therapy
George Poste,Richard Kirsh +1 more
TL;DR: The current status of efforts to target cytotoxic agents to tumor cells using antitumor antibodies and particulate drug carriers such as liposomes and microspheres is reviewed.
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Lipid emulsions as drug delivery systems.
Stanley S. Davis,Clive Washington,Philip West,Lisbeth Illum,Garry Liversidge,Larry A. Sternson,Richard Kirsh +6 more
TL;DR: This article will consider recent studies on the use of lipid emulsions as drug delivery systems and will concentrate on the intravenous route of administration.
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An Emulsion Formulation of Amphotericin B Improves the Therapeutic Index When Treating Systemic Murine Candidiasis
Richard Kirsh,Robin S. Goldstein,Joan B. Tarloff,D. Parris,Jerry B. Hook,Nabil Hanna,Peter J. Bugelski,George Poste +7 more
TL;DR: The efficacy and reduced toxicity of the amphotericin B emulsion are findings suggesting that the emulsion formulation is preferable to Fungizone.