Based on engineered or bacterial nucleases, the development of genome editing technologies has opened up the possibility of directly targeting and modifying genomic sequences in almost all eukaryotic cells. Genome editing has extended our ability to elucidate the contribution of genetics to disease by promoting the creation of more accurate cellular and animal models of pathological processes and has begun to show extraordinary potential in a variety of fields, ranging from basic research to applied biotechnology and biomedical research. Recent progress in developing programmable nucleases, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat (CRISPR)–Cas-associated nucleases, has greatly expedited the progress of gene editing from concept to clinical practice. Here, we review recent advances of the three major genome editing technologies (ZFNs, TALENs, and CRISPR/Cas9) and discuss the applications of their derivative reagents as gene editing tools in various human diseases and potential future therapies, focusing on eukaryotic cells and animal models. Finally, we provide an overview of the clinical trials applying genome editing platforms for disease treatment and some of the challenges in the implementation of this technology.

/pdf/applications-of-genome-editing-technology-in-the-targeted-2giausc34s.pdf

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

https://bioone.org/journals/harvard-papers-in-botany/volume-13/issue-2/1043-4534-13.2.299/Flora-of-China/10.3100/1043-4534-13.2.299.pdf

Flora of China

Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects.

Medically Important Fungi: A Guide to Identification

evidence showing similar craniopharyngioma and ada the jaw. I am delighted that a fifi appeared. It will remain the on the pathology of tumours system for some time yet. increased considerably in ti result it is now not so comfor and only reads with ease towards the centre of the bx truly a reference book r, \"readers\" book. ities between Congress held in Budapest during Lmantinoma of almost exclusively devoted to s steroid metabolism, their receptors th edition has effects on experimental mammary standard work and advanced human breast can of the nervous mention is made ofsome growth fa The book has main thrust of the book is to hickness; as a possible therapeutic implications. table to handle this reflects the intended readershil when opened As an outsider to this particuk ook. It is now breast cancer studies, I found 1 ather than a unsatisfactory. This was not becai presentations, which in themselves WR TIMPERLEY and well illustrated. The main de] overall lack of orientation and linkage. The briefdiscussion at the book helps no further. I suspect Practical Medical Microbiology. 13th ed. Ed JG Collee, JP Duguid, AG Fraser, BP Marmion (Pp 918; £29.50.) Churchill Livingstone. 1989. ISBN 0443-02323-8.

https://jcp.bmj.com/content/jclinpath/42/12/1315.1.full.pdf

Practical Medical Microbiology

ObjectivesCurcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology.



Key findings Research carried out using different in-vitro and in-vivo techniques of biological evaluation supports most of the claims.



Summary This review presents the botany, chemistry, traditional uses and pharmacological data of the plant.

https://onlinelibrary.wiley.com/doi/pdf/10.1211/jpp.61.01.0003

Curcuma zedoaria Rosc.(white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

Ocimum gratissimum is a well-known plant used in the Indian system of medicine. Folklore medicine claims its use in headache, fever, diarrhoea, pneumonia etc. Research carried out using different in vitro and in vivo techniques of biological evaluation supports most of the claims. This review presents the ethnobotanical, natural product chemistry, pharmacological, clinical and toxicological data of the plant.

/pdf/ocimum-gratissimum-a-review-of-its-chemical-pharmacological-18ylagc0uy.pdf

Ocimum gratissimum: A Review of its Chemical, Pharmacological andEthnomedicinal Properties

Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats

We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mgkg(-1) i.p.) and streptozotocin (STZ) (60 mgkg(-1) i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test. Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.

Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin‐nicotinamide diabetic rats

The objective of the present study is to explore the anticancer activity of the ethanolic and aqueous extracts of the Dendrophthoe falcata in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line. Anticancer activity of ethanolic and aqueous extracts of D. falcata was evaluated in EAC Swiss albino mice at the doses of 200 and 400 mg/kg body weight orally. Both extracts at both doses were administered for 13 consecutive days. After 24 h of the last dose and then eighteen hours of fasting, the mice were sacrificed and antitumor effect of ethanolic and aqueous extracts was as- sessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. Ethanolic and aqueous extracts showed significant decrease in (p<0.0001) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Haematological profiles such as red blood cell (RBC), haemoglobin, and white blood cell (WBC) count reverted to normal level in treated mice. The results demon- strated that the extract has potent dose dependent anticancer activity comparable to that of cisplatin. Aqueous extract at both doses (200 and 400 mg/kg) and ethanolic extract at 400 mg/kg dose showed potent anticancer activity.

/pdf/antitumor-activity-of-dendrophthoe-falcata-against-ehrlich-31vz4eerzd.pdf

Richard Lobo

Papers

Curcuma zedoaria Rosc.(white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties

Ocimum gratissimum: A Review of its Chemical, Pharmacological andEthnomedicinal Properties

Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats

Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin‐nicotinamide diabetic rats

Antitumor Activity of Dendrophthoe falcata against Ehrlich Ascites Carcinoma in Swiss Albino Mice