Richard W. Thies

TL;DR: Retinoic acid, 7, 13, 14, and 19 inhibited papilloma tumor formation in mice, and toxicity testing indicated that 7 was more toxic than 1, 13 and 14 were less toxic than 2, and 13 and 13 were less Toxic than 1.

TL;DR: A series of conformationally restricted retinoids were synthesized and screened in two assays used to measure the ability of retinoid to control cell differentiation, namely, the reversal of keratinization in tracheal organ culture from vitamin A deficient hamsters and the inhibition of the induction of mouse epidermal ornithine decarboxylase by a tumor promoter.