A novel method for synthesis of silica nanoparticles.

Advanced bioanalysis, including accurate quantitation, has driven the need to understand biology and medicine at the molecular level. Bioconjugated silica nanoparticles have the potential to address this emerging challenge. Particularly intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery, have also been found for silica nanoparticles. In this review, we describe the synthesis, bioconjugation, and applications of silica nanoparticles in different bioanalysis formats, such as selective tagging, barcoding, and separation of a wide range of biomedically important targets. Overall, we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology, genomics, proteomics and medicine.

https://link.springer.com/content/pdf/10.1007%2Fs12274-008-8018-3.pdf

Bioconjugated silica nanoparticles: Development and applications

Fluorescent dye-doped silica nanoparticles: new tools for bioapplications

Purpose – The purpose of this paper is to investigate the tribological properties of liquid paraffin with SiO2 nanoparticles additive made by a sol‐gel method.Design/methodology/approach – The tribological properties of the SiO2 nanoparticles as an additive in liquid paraffin are measured using a ball‐on‐ring wear tester to determine the optimal additive concentration. The mechanism that wear and friction are reduced is studied using scanning electron microscopy (SEM), energy dispersive spectrometry (EDS), and atomic force microscope (AFM).Findings – Experimental results indicate that the sizes of the synthesized SiO2 nanoparticles are distributed uniformly and that the optimal concentrations of SiO2 nanoparticles in liquid paraffin is associated with better tribological properties than pure paraffin oil, and an anti‐wear (AW) ability that depends on the particle size.Originality/value – It is shown in the paper that by reducing friction and AW, the lubricant prepared by the methods described can prolong ...

Size effects of SiO2 nanoparticles as oil additives on tribology of lubricant

The surfaces of silica particles were molecularly imprinted with an α-chymotrypsin transition-state analogue (TSA) by utilizing the technique of template-directed synthesis of mineralized materials. The resulting catalytic particles hydrolyzed amides in an enantioselective manner. A mixture of a nonionic surfactant and the acylated chymotrypsin TSA, with the TSA acting as the headgroup at the surfactant−water interface, was used to form a microemulsion for silica particle formation. Incorporation of amine-, dihydroimidazole-, and carboxylate-terminated trialkoxysilanes into the particles during imprinting resulted in enhancement of the rates of amide hydrolysis. Acylated imprint molecules formed more effective imprints in the presence of the functionalized silanes than nonacylated imprint molecules. Particles surface-imprinted with the chymotrypsin TSA were selective for the trypsin substrate, and particles surface-imprinted with the l-isomer of the enzyme TSA were enantioselective for the d-isomer of the...

Ritva Lindberg

Papers

Preparation of silica particles utilizing the sol-gel and the emulsion-gel processes