Showing papers by "Rob L. H. Jansen published in 2022"
TL;DR: In this paper , the authors investigated whether adherence to the WCRF/AICR recommendations is associated with CUP risk and found that the highest adherence appeared to be associated with decreased cancer of unknown primary (CUP) risk.
3 citations
TL;DR: In this article , the authors investigated whether vegetables and fruits are associated with cancer of unknown primary (CUP) risk and found no associations between total vegetable and fruit consumption (combined or as separate groups) and CUP risk.
Abstract: Cancer of Unknown Primary (CUP) is a metastatic cancer for which the primary lesion remains unidentifiable during life and little is also known about the modifiable risk factors that contribute to its development. This study investigates whether vegetables and fruits are associated with CUP risk.We used data from the prospective Netherlands Cohort Study on Diet and Cancer which includes 120,852 participants aged between 55 and 69 years in 1986. All participants completed a self-administered questionnaire on cancer risk factors at baseline. Cancer follow-up was established through record linkage to the Netherlands Cancer Registry and the Dutch Pathology Registry. As a result, 867 incident CUP cases and 4005 subcohort members were available for case-cohort analyses after 20.3 years of follow-up. Multivariable adjusted hazard ratios were calculated using proportional hazards models.We observed no associations between total vegetable and fruit consumption (combined or as separate groups) and CUP risk. However, there appeared to be an inverse association between the consumption of raw leafy vegetables and CUP. With respect to individual vegetable and fruit items, we found neither vegetable nor fruit items to be associated with CUP risk.Overall, vegetable and fruit intake were not associated with CUP incidence within this cohort.
3 citations
TL;DR: In this paper , the authors investigated whether vegetables and fruits are associated with cancer of unknown primary (CUP) risk and found no associations between total vegetable and fruit consumption (combined or as separate groups) and CUP risk.
Abstract: Cancer of Unknown Primary (CUP) is a metastatic cancer for which the primary lesion remains unidentifiable during life and little is also known about the modifiable risk factors that contribute to its development. This study investigates whether vegetables and fruits are associated with CUP risk.We used data from the prospective Netherlands Cohort Study on Diet and Cancer which includes 120,852 participants aged between 55 and 69 years in 1986. All participants completed a self-administered questionnaire on cancer risk factors at baseline. Cancer follow-up was established through record linkage to the Netherlands Cancer Registry and the Dutch Pathology Registry. As a result, 867 incident CUP cases and 4005 subcohort members were available for case-cohort analyses after 20.3 years of follow-up. Multivariable adjusted hazard ratios were calculated using proportional hazards models.We observed no associations between total vegetable and fruit consumption (combined or as separate groups) and CUP risk. However, there appeared to be an inverse association between the consumption of raw leafy vegetables and CUP. With respect to individual vegetable and fruit items, we found neither vegetable nor fruit items to be associated with CUP risk.Overall, vegetable and fruit intake were not associated with CUP incidence within this cohort.
1 citations
TL;DR: There is a nonsignificant positive association between type 2 diabetes mellitus (T2DM) status and CUP risk and that the association became stronger in women in stratified analyses.
Abstract: Objective Cancer of unknown primary (CUP) is a metastatic malignancy with an unidentifiable primary tumour origin. Previous studies suggest that type 2 diabetes mellitus (T2DM) and CUP risk are associated. This study examines the association in greater depth by investigating T2DM status, T2DM duration, T2DM age at diagnosis, and medication that was being used in relation to CUP. Methods Data were utilized from the Netherlands Cohort Study, a prospective cohort that includes 120 852 participants aged 55–69 years at baseline in 1986. All participants completed a self-administered questionnaire on cancer risk factors. CUP cases were identified through record linkage with the Netherlands Cancer Registry and Dutch Pathology Registry. After 20.3 years of follow-up, 963 incident CUP cases and 4288 subcohort members were available for case-cohort analyses. Proportional hazards models were employed to estimate multivariable-adjusted hazard ratios (HRs). Results Overall, we observed a nonsignificant positive association between T2DM status and CUP risk [HR, 1.35; 95% confidence interval (CI), 0.92–1.99], which increased in women after stratification for sex (HR, 1.55; 95% CI, 0.90–2.64). For participants who were aged less than 50 years at diagnosis of T2DM, a statistically significant positive association was found in relation to CUP (HR, 2.42; 95% CI, 1.26–4.65), compared with participants without T2DM. Conclusion Our findings indicate that there is a nonsignificant positive association between T2DM and CUP risk and that the association became stronger in women in stratified analyses.
1 citations