Showing papers by "Robert A. Levine published in 1972"

The effect of prostaglandin E1 on canine gastric acid secretion and gastric mucosal blood flow

Abstract: Prostaglandin E1 (PGE1) was administered intravenously at the rate of either 1 or 2µg/kg/min to conscious dogs with vagally denervated gastric pouches under conditions of maximal histamine stimulation. Changes in the gastric mucosal circulation were measured by the aminopyrine clearance technique. Prostaglandin E1 significantly inhibited volume and acid output and such inhibition appeared to vary proportionally to the concentration of PGE1 used. The inhibitory effect of PGE1 on gastric secretion was also associated with a marked reduction in gastric mucosal blood flow. A biphasic response was noted in (R), a ratio reflecting the relationship between changes in gastric mucosal blood flow and rate of gastric secretion. Initially, there was a reduction inR suggesting that blood was being shunted from the mucosal circulation. As the inhibition of gastric secretion continued and became maximal,R increased, indicating that the persistent reduction in gastric mucosal blood flow was secondary to an inhibition of gastric secretion. These studies indicate that PGE1 is a potent inhibitor of histamine-stimulated gastric acid secretion in the dog and that the sustained inhibitory effects of PGE1 are probably due to direct action at the oxyntic cell level.