Robert Deziel

TL;DR: BILD 1263 is reported on, which to the authors' knowledge is the first HSV RNR subunit-association inhibitor with antiviral activity in vivo and may lead to the design of new strategies to treat herpesvirus infections in humans.

TL;DR: Norvaline was identified as a chemically stable replacement for the P1 residue of Ac-DDIVPC-OH which was also compatible with activated carbonyl functionalities.

TL;DR: Novel, chiral 3,4-dihydroquinoxalin-2(1H)-one and piperazine-2,5-dione aryl hydroxamates showing selectivity (up to 40-fold) for human HDAC6 over other class I/IIa HDACs suggests new possibilities for use of chiral compounds in selective HDAC isoform inhibition.

TL;DR: A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized with the thiophene analogues being superior to thiazole, pyridine, isoindoline and benzofuran based inhibitors.

TL;DR: The use of both tri- and tetrasubstituted urea functionalities gave effective inhibitors of HCMV protease, and Benzyl substitution of the urea moiety was beneficial, especially when strong electron-withdrawing groups where attached at the para position.