An imaging system for performing forward scanning imaging for application to therapeutic and diagnostic devises used in medical procedures. The imaging system includes forward directed optical coherence tomography (OCT), and non-retroreflected forward scanning OCT. Also interferometric imaging and ranging techniques and fluorescent, Raman, two-photon, and diffuse wave imaging can be used. The forward scanning mechanisms include a cam attached to a motor, pneumatic devices, a pivoting device, piezoelectric transducers, electrostatic driven slides for substantially transverse scanning; counter-rotating prisms, and offset lenses are used for arbitrary scanning. The imaging system of the invention is applied to hand held probes including probes integrated with surgical probes, scalpels, scissors, forceps and biopsy instruments. Hand held probes include forward scanning lasers. The imaging system is also applicable to laparoscopes and endoscopes for diagnostc and therapeutic intervention in body orifices, canals, tubes, ducts, vessels and cavities of the body. The imaging system includes application to surgical and high numerical aperture microscopes. An important application of the invention is implantation of the optical probe for periodic or continuous extraction of information from the tissue site where implanted.

Methods and apparatus for forward-directed optical scanning instruments

An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating an image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.

Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope

Ultra-small optical probes comprising a single-mode optical fiber and a lens which has substantially the same diameter as the optical fiber. The optical fiber and lens are positioned in a probe housing which is in the form of an insertional medical device such as a guidewire. Connector elements are provided to facilitate the attachment of the probe to an optical system and the quick disconnection of the probe from the optical system. The probe is used to obtain optical measurements in situ in the body of an organism and can be used to guide interventional procedures by a surgeon.

Ultra-small optical probes, imaging optics, and methods for using same

Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects.

Circulatory monitoring systems and methods

An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.

Fiber optic imaging endoscope interferometer with at least one faraday rotator

An optical fiber fluid flow device is provided for in vivo determination of blood flow in arteries. The device includes a fiber optical fluid pressure measuring device having at least first and second optical fiber sensors which optical fiber sensors are positioned in the blood passage and in a restricted flow area in the blood passage and the two fiber optical pressure fluid sensors are connected to an interferometer associated with an opto-electronic demodulator which has an output signal representing the differential pressure between the two sensed area. The device also has utility in industrial applications.

Fluid flow sensing apparatus for in vivo and industrial applications employing novel differential optical fiber pressure sensors

A fiber optical fiber fluid flow measuring device is provided for in vivo determination of blood flow in arteries. The device includes a fiber optical fluid differential pressure measuring device having at least one optical fiber sensor which optical fiber sensor is positioned in the blood flow passage in a restricted flow area. The fiber optical differential pressure fluid sensor is connected to a divided interferometer associated with an opto-electronic demodulator which has an output signal representing the differential pressure in the sensed area. The device also has utility in industrial applications.

Robert E. Einzig

Papers

Fluid flow sensing apparatus for in vivo and industrial applications employing novel differential optical fiber pressure sensors

Fluid flow sensing apparatus for in vivo and industrial applications employing novel optical fiber pressure sensors