One dimensional man

While the study of psychology has offered little in the way of explaining the creative process, Koestler examines the idea that we are at our most creative when rational thought is suspended--for example, in dreams and trancelike states. All who read The Act of Creation will find it a compelling and illuminating book.

The Act of Creation

https://psycnet.apa.org/doi/10.1037/h0077132

Dropping out of treatment: a critical review.

An information system consists of, at least, a PERSON of a certain PSYCHOLOGICAL TYPE who faces a PROBLEM within some ORGANIZATIONAL CONTEXT for which he needs EVIDENCE to arrive at a solution, where the evidence is made available through some MODE OF PRESENTATION. This defines the key variables comprising a Management Information System MIS. It is argued that most research and development to date on MIS has assumed only one underlying psychological type, one class of problem types, one or two methods of generating evidence, and, finally, one mode of presentation. Other states are suggested for all these key variables. The result is the outline of a systematic research program on MIS.

https://www.jstor.org/stable/info/2629445

A Program for Research on Management Information Systems

An in vivo method for screening drugs, food additives, and other chemicals that might cause chromosomal aberrations has been tested. It is reliable, easy, and very much more rapid than the traditional method.

A rapid in vivo test for chromosomal damage

Of nine studies in vitro, six have indicated some degree of induced chromosomal breakage after exposure to LSD; three failed to confirm these results. The damage, when found, was generally of the chromatid type, arising during or after DNA synthesis. This damage, with one exception, was the result of concentrations of drug and durations of exposure which could not be achieved in humans with reasonable dosages. There did not appear to be a dose-response relation. The magnitude of damage, when found, was in the range encompassing the effects of many commonly used substances. The absence in vitro of excretory and detoxifying systems present in vivo, as well as several negative reports, cast doubt on the relevance of in vitro results. In 21 chromosomal studies in vivo, 310 subjects were examined. Of these, 126 were treated with pure LSD; the other 184 were exposed to illicit, "alleged" LSD. A maximum of only 18 of 126 (14.29 percent) of the subjects in the group exposed to pure LSD showed higher frequency of chromosome aberration than the controls. In contrast, a maximum of 90 of 184 (48.91 percent) of the subjects taking illicit LSD showed an increase in frequency of aberrations. Of all the subjects reported to have chromosome damage, only 18 of the 108 (16.67 percent) were exposed to pure LSD. The frequency of individuals with chromosomal damage reported among illicit drug users was more than triple that associated with the use of pharmacologically pure LSD. We conclude that chromosome damage, when found, was related to the effects of drug abuse in general and not, as initially reported, to LSD alone. We believe that pure LSD ingested in moderate dosages does not produce chromosome damage detectable by available methods. No significant work on carcinogenic potential of LSD has been reported so far. No cause-and-effect relation and no increase in the incidence of neoplasia among LSD users have been demonstrated. Case reports (three in 4.0 years) of leukemia and other neoplasia in this population are rare. The results of early chromosome studies suggested that true genetic damage might be a consequence of LSD exposure. The comprehensive evidence from studies on drosophila indicates no mutagenic effect from 0.28 to 500 microg of LSD per milliliter and a definite mutagenic effect from 2,000 to 10,000 microg/ml; this is consistent with a threshold response or a sigmoid dose-effect relation. We believe that LSD is, in fact, a weak mutagen, effective only in extremely high doses; it is unlikely to be mutagenic in any concentration used by human subjects. Circular dichroism experiments suggested that the specific mechanism of action of LSD on DNA may be a direct interaction resulting in conformational changes in the DNA helix. These changes are unlikely to result in a decrease of internal stability sufficient to cause breakage of chromosomes, but they may be the physical basis of the weak mutagenicity. Early chromosomal studies implicated LSD as a potential cause of congenital malformations, fetal wastage, and germinal chromosome damage. First reports of a teratogenic effect in hamsters and rats have not been confirmed. A review of 15 rodent studies indicated a wide range of individual, strain, and species susceptibility to the effects of LSD. The applicability of such investigations to man is doubtful. In a study of human pregnancies, those exposed to illicit LSD had an elevated rate of spontaneous abortions. There is no reported instance of a malformed child born to a woman who ingested pure LSD; there are six cases of malformation associated with exposure to illicit LSD, four of which have similar limb defects. Given, however, the high frequency of unexplained "spontaneous" birth defects, the rare occurrence of malformed infants born to women who used illicit LSD may be coincidental. While there is no evidence that pure LSD is teratogenic in man, the use of any drug during pregnancy requires that its potential benefits significantly outweigh its potential hazards. From our own work and from a review of the literature, we believe that pure LSD ingested in moderate doses does not damage chromosomes in vivo, does not cause detectable genetic damage, and is not a teratogen or a carcinogen in man. Within these bounds, therefore, we suggest that, other than during pregnancy, there is no present contraindication to the continued controlled experimental use of pure LSD. Note added in proof: A brief review has been brought to our attention. Although based on a sample of only 15 studies the author reached conclusions similar to our own (92).

https://science.sciencemag.org/content/sci/172/3982/431.full.pdf

LSD and Genetic Damage

Based on the frequently reported similarities between creative and psychedelic (drug-induced, consciousness-expansion) experiences, a preliminary study was conducted to explore the effects of psychedelic agents (LSD-25, mescaline) on creative problem-solving ability. Twenty-seven professionally employed males were given a single psychedelic experience in 1 of 7 small groups (ns = 3 or 4) following extensive selection and preparatory procedures. This drug-induced problem-solving session was carefully structured with particular focus on establishing Ss' expectancies and a psychosocial milieu conducive to creative activity. Tentative findings based on tests of creativity, on subjective reports and self ratings, and on the utility of problem solutions suggested that, if given according to this carefully structured regimen, psychedelic agents seem to facilitate creative problem-solving, particularly in the “illumination phase.” The results also suggest that various degrees of increased creative ability may con...

Psychedelic Agents in Creative Problem-Solving: A Pilot Study:

The Personal Orientation Inventory (POI), a recently developed measure of self-actualizing tendencies, was administered on 2 occasions to 48 college students to determine the stability, independence, and utility of 10 subscales. Stability coefficients and intercorrelations indicated that 3 of the 12 scales, Inner Direction, Time Competence, and Self-actualization Value, accounted for almost all the variance. Since many of the intercorrelations approximated the scales' reliabilities, it was concluded that performance on the POI could be more accurately and parsimoniously expressed in terms of fewer dimensions.

Stability and internal consistency of a measure of self-actualization.

(1970). Personality Subtypes of Male and Female Alcoholic Patients. International Journal of the Addictions: Vol. 5, No. 1, pp. 99-113.

Personality subtypes of male and female alcoholic patients.

ALTHOUGH countless writers have observed that the personal views of staff members toward the alcoholic is an important factor in treatment, the problem has seldom been explored systematically. It is well known that overindulgence in alcohol often elicits strong negative reactions from hospital staff. In December 1964, the Alcoholism Study Group at Mendocino State Hospital noted in their report that, "Within the hospital system, we have failed to identify the built-in attitudes and policies that defeat creative treatment approaches." Similarly, Moore and Ramseur 1 observed that this uncontrolled hedonism evokes various responses, from envy to repugnance, which have decided effect on the alcoholic patient. In addition to expressed attitudes, unconscious reactions by staff members to acting-out forms of disturbance may actually encourage the deviant behavior or force its suppression. In either case, the result is antitherapeutic. With the exception of Selzer's 2 observational study of the relationship between negative attitudes

Robert E. Mogar

Papers

LSD and Genetic Damage

Psychedelic Agents in Creative Problem-Solving: A Pilot Study:

Stability and internal consistency of a measure of self-actualization.

Personality subtypes of male and female alcoholic patients.

Staff Attitudes Toward the Alcoholic Patient