The invention relates to a multiparticulate modified release composition that in operation delivers an active ingredient in a pulsed or bimodal manner. The multiparticulate modified release composition comprises an immediate release component and a modified release component; the immediate release component comprising a first population of active ingredient containing particles and the modified release component comprising a second population of active ingredient containing particles coated with a controlled release coating; wherein the combination of the immediate release and modified release components in operation deliver the active ingredient in a pulsed or a bimodal manner. The invention also relates to a solid oral dosage form containing such a multiparticulate modified release composition. The plasma profile achieved by the multiparticulate modified release composition is advantageous in reducing patient tolerance to the active ingredient and in increasing patient compliance by reducing dosage frequency.

Multiparticulate modified release composition

A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.

Controlled release hydrocodone formulations

The invention relates to urethane(meth)acrylates containing siloxane groups and able to undergo free-radical polymerization, which contain: a) at least one compound containing at least one active hydrogen atom and at least one α,β-ethylenically unsaturated double bond able to undergo free-radical polymerization per molecule; b) at least one diisocyanate; c) at least one compound which contains two active hydrogen atoms per molecule; and d) at least one compound containing at least one active hydrogen atom and at least one siloxane group per molecule. The invention also relates to water-soluble or water-dispersible polymers in which said urethane(meth)acrylates are incorporated by polymerisation, the use of said polymers and cosmetic agents containing said polymers.

Urethane(meth)acrylates containing siloxane groups and able to undergo free-radical polymerisation

The present invention relates to aqueous compositions comprising component (A) which comprises at least one water-soluble component comprising at least one functional group that undergoes a crosslinking reaction, preferably upon drying and/or heating; and component (B) which comprises at least one film-forming material. In particular the composition is a coating composition comprising: (A) at least one polyamidoamine-epihalohydrin resin; and (B) at least one material selected from flexibilizing materials, crosslink inhibiters and combinations thereof in an amount sufficient to impart a cuttability value of less than about 15 to a substrate coated with the coating composition. Component (B) is preferably at least one polymer comprising repeating units derived from an alkyl halide having at least one double bond and an alkene, such as ethylene vinyl chloride. Coated substrates such as coated building units, such as ceiling tiles and wall boards, as well as methods of producing such coated substrates are also provided.

Compositions for imparting desired properties to materials

Disclosed is a hair conditioning composition comprising: a non-volatile silicone compound which has a molecular weight of from about 100,000 to about 1,500,000 and has a viscosity of from about 500,000 to about 50,000,000 mPa.s; a volatile compound selected from the group consisting of an isoparaffin hydrocarbon having a boiling point of from about 60 to about 260°C, a volatile silicone compound having from 2 to 7 silicon atoms, and mixtures thereof; and a frizz control agent selected from the group consisting of: PEG-modified glycerides; PEG-modified glyceryl fatty acid esters; and mixtures thereof.

Hair conditioning composition comprising silicones and frizz control agents

This invention relates to an aqueous acrylic resin crosslinked with difunctional acrylated urethane oligomers which are used in nail polish compositions. The nail polish compositions exhibit quick dry time, excellent leveling, good water/detergent resistance, abrasion resistance and durability with good adhesion to nails for long-wear nail polish applications and yet are easily removed from the nail.

Aqueous nail polish compositions containing acrylic resins crosslinked with acrylated urethane oligomers

Provided is a process useful for preparing acrylic polymers of methacrylic acid and ethyl acrylate. The process provides polymers useful as enteric coatings for medicaments in solid form, said coatings having improved effectiveness, reproducibility and coating efficiency. Also provided are medicaments in solid form coated with such polymers.

Process for the preparation of acrylic polymers for pharmaceutical coatings

Provided is a process useful for making acrylic polymers of methacrylic acid having improved shear stability. The process provides polymers useful as enteric coatings for medicaments having improved coating efficiency of pharmaceutical forms. Also provided are medicaments in solid form coated with said polymers.

Process for improving mechanical shear stability of acrylic enteric polymers

A latex composition for hair care containing a hybrid-graft copolymer of a sulfopolyester and an acid-functional polymer segment. The acid-functional polymer segment is formed from at least one acid-functional monomer, at least one ethylenically unsaturated monomer, and at least one amide-containing monomer. Such compositions exhibit superior curl retention even at high humidity.

Robert Gow-Sheng Kingsport Chen

Papers

Aqueous nail polish compositions containing acrylic resins crosslinked with acrylated urethane oligomers

Process for the preparation of acrylic polymers for pharmaceutical coatings

Process for improving mechanical shear stability of acrylic enteric polymers

Latex compositions for hair care