R
Robert L. Modlin
Researcher at University of California, Los Angeles
Publications - 342
Citations - 45696
Robert L. Modlin is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 112, co-authored 329 publications receiving 42972 citations. Previous affiliations of Robert L. Modlin include West Los Angeles College & Howard Hughes Medical Institute.
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Journal ArticleDOI
Plasticity of antimicrobial and phagocytic programs in human macrophages
Dennis Montoya,Manali Mehta,Benjamin G. Ferguson,Rosane M. B. Teles,Stephan R. Krutzik,Daniel Cruz,Matteo Pellegrini,Robert L. Modlin +7 more
TL;DR: An approach to induce MΦ plasticity that provides the potential for re‐educating M Φ function in human mycobacterial disease to promote host defense and limit pathogenesis is demonstrated.
Journal Article
B7-1, But Not CD28, Is Crucial for the Maintenance of the CD4+ T Cell Responses in Human Leprosy
Katia Schlienger,Koichi Uyemura,Denis Jullien,Peter A. Sieling,Thomas H. Rea,Peter S. Linsley,Robert L. Modlin +6 more
TL;DR: Peripheral blood T cell responses in the lepromatous form were strongly regulated by CD28 during T cell activation, in contrast to the tuberculoid form, suggesting that B7-1 costimulation could play a role in maintaining a strong immune response to the pathogen.
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Demonstration in situ of subsets of T-lymphocytes in sarcoidosis
TL;DR: T-cells expressing the suppressor/cytotoxic phenotype were found predominantly in lymphocytic mantles surrounding sarcoidal granulomas, whereas cells displaying the helper/inducer phenotype were distributed diffusely throughoutgranulomas.
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Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences
Kayvan Niazi,Maria Teresa Ochoa,Peter A. Sieling,Nanette E Rooke,Anna K. Peter,Pamela Mollahan,Micah Dickey,Shahrooz Rabizadeh,Thomas H. Rea,Robert L. Modlin +9 more
TL;DR: Evaluation of trafficking patterns revealed that all four human CD1‐derived targeting sequences delivered antigen to the MHC class II antigen presentation pathway, to early/recycling, early/sorting and late endosomes/lysosomes.
Journal ArticleDOI
Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.
Rosane M. B. Teles,Jing Lu,Maria Tió-Coma,Isabela Maria Bernardes Goulart,Sayera Banu,Deanna A. Hagge,Kidist Bobosha,Tom H. M. Ottenhoff,Matteo Pellegrini,Annemieke Geluk,Robert L. Modlin +10 more
TL;DR: Data indicate that RRs involve a systemic upregulation of IFN-γ downstream genes including GBP family members as part of the host antimicrobial response against mycobacteria.