R
Robert M. Nerem
Researcher at Parker H. Petit Institute for Bioengineering & Bioscience
Publications - 218
Citations - 19517
Robert M. Nerem is an academic researcher from Parker H. Petit Institute for Bioengineering & Bioscience. The author has contributed to research in topics: Endothelial stem cell & Shear stress. The author has an hindex of 74, co-authored 218 publications receiving 18774 citations. Previous affiliations of Robert M. Nerem include University of Texas System & Chonbuk National University.
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Journal ArticleDOI
Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.
Ken'ichi Nishida,David G. Harrison,J. P. Navas,A. A. Fisher,S. P. Dockery,M. Uematsu,Robert M. Nerem,Robert Alexander,T. J. Murphy +8 more
TL;DR: The unique features of the endothelial cell NO synthase, particularly in the amino terminal portion of the molecule, may provide for novel regulatory influences of enzyme activity and localization.
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The Elongation and Orientation of Cultured Endothelial Cells in Response to Shear Stress
M. J. Levesque,Robert M. Nerem +1 more
TL;DR: The results show that endothelial cells orient with the flow direction under the influence of shear stress, the time required for cell alignment with flow direction is somewhat longer than that needed for cell elongation, and there is a strong correlation between the degree of alignment and endothelial cell shape.
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Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State: Role of a Superoxide-Producing NADH Oxidase
G.W. De Keulenaer,D.C. Chappell,Nobukazu Ishizaka,Robert M. Nerem,Robert Alexander,Kathy K. Griendling +5 more
TL;DR: Data are consistent with the hypothesis that continuous oscillatory shear causes a sustained activation of pro-oxidant processes resulting in redox-sensitive gene expression in human endothelial cells.
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Dynamic Mechanical Conditioning of Collagen-Gel Blood Vessel Constructs Induces Remodeling In Vitro
TL;DR: It is concluded that dynamic mechanical conditioning during tissue culture leads to an improvement in the properties of tissue-engineered blood vessel constructs in terms of mechanical strength and histological organization.
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Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress
M. Uematsu,Y. Ohara,J. P. Navas,K. Nishida,T. J. Murphy,Robert Alexander,Robert M. Nerem,David G. Harrison +7 more
TL;DR: The data suggest that ecNOS mRNA expression is regulated by K+ channel opening, but not by activation of PKC, and that shear not only enhances ecN OS mRNA expression but increases capacity of endothelial cells to release NO.