scispace - formally typeset
Search or ask a question

Showing papers by "Robert N. Baldassano published in 2001"


Journal ArticleDOI
TL;DR: High rates of postoperative Crohn’s disease recurrence are associated with severe disease at the time of surgery, colonic Crohn's disease, and the preoperative use of 6-MP, which is likely to suffer from a more aggressive disease and would benefit from postoperative 6- MP prophylaxis.

76 citations


Journal Article
TL;DR: In IBD, growth failure may be the only clinical presentation; it is imperative to perform a detailed history and physical examination to search for other systemic and gastrointestinal manifestations of the disease.
Abstract: Once considered rare in pediatric practice, chronic inflammatory bowel disease (IBD) is now being recognized with increasing frequency in children of all ages. In IBD, growth failure may be the only clinical presentation; it is imperative to perform a detailed history and physical examination to search for other systemic and gastrointestinal manifestations of the disease. IBD can have a significant impact on linear growth, weight gain, and bone mineralization, and can cause delays in the onset of puberty. Delays in growth and sexual development can be early indicators of disease activity, and assessment of growth and development should be performed frequently. Nutritional therapy is important not only to correct undernutrition, but also as therapy for IBD. Delayed puberty can have a significant impact on the self-esteem of the adolescent patient and diminish final adult height. Loss of bone mineral density is especially significant during a period in which the majority of bone accretion is expected to occur. These issues present unique problems to the gastroenterologist caring for a child or adolescent with IBD and require specific types of monitoring and interventions.

31 citations


Journal ArticleDOI
TL;DR: Failure of single-toxin assays to detect Clostridium difficile infection in pediatric inflammatory bowel disease is a major setback in efforts to understand the cause of bowel disease in children.

29 citations