R
Robert Nufer
Researcher at Novartis
Publications - 3
Citations - 43
Robert Nufer is an academic researcher from Novartis. The author has contributed to research in topics: Metabolite & Siponimod. The author has an hindex of 2, co-authored 3 publications receiving 30 citations.
Papers
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Journal ArticleDOI
Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism.
Ulrike Glaenzel,Yi Jin,Robert Nufer,Wenkui Li,Kirsten Schroer,Sylvie Adam-Stitah,Sjoerd Peter van Marle,Eric Legangneux,Hubert Borell,Alexander David James,Axel Meissner,Gian Camenisch,Anne Gardin +12 more
TL;DR: The selective inhibitor and recombinant enzyme results identified cytochrome P450 2C9 (CYP2C9) as the predominant contributor to the human liver microsomal biotransformation of siponimod, with minor contributions from CYP3A4 and other cyto Chrome P450 enzymes.
Journal ArticleDOI
Cytostar-T plates--a valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?
TL;DR: The full scan mass spectra of recovered metabolites showed higher quality allowing the characterization of metabolites without any further sample pre-treatment, a major advantage which could further speed-up the structure elucidation process of metabolites in complex biological matrices.
Patent
Dérivés de pyrimidine-4-yl)oxy)-1 h-indole-1-carboxamide et leur utilisation
Ulrike Glaenzel,Robert Nufer +1 more
TL;DR: The authors concerne certains metabolites de N-(1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidine-4-yl)oxy)1Hindole-1-carboxamide).