R
Robert P. Millar
Researcher at University of Pretoria
Publications - 412
Citations - 23681
Robert P. Millar is an academic researcher from University of Pretoria. The author has contributed to research in topics: Gonadotropin-releasing hormone & Receptor. The author has an hindex of 82, co-authored 405 publications receiving 22465 citations. Previous affiliations of Robert P. Millar include Groote Schuur Hospital & Medical Research Council.
Papers
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Journal ArticleDOI
Gonadotropin-Releasing Hormone Receptors
Robert P. Millar,Robert P. Millar,Zhi-Liang Lu,Adam J. Pawson,Colleen A. Flanagan,Kevin Morgan,Stuart Maudsley +6 more
TL;DR: Delineation of the structural elements in GnRH and the receptor, which facilitate differential signaling, will contribute to the development of novel interventive GnRH analogs.
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Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
TL;DR: This review aims to provide a comprehensive account of the state-of-the-art in the field of kisspeptin physiology by covering in-depth the consensus knowledge on the major molecular features, biological effects, and mechanisms of action ofkisspeptins in mammals and, to a lesser extent, in nonmammalian vertebrates.
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Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor
TL;DR: The structure and Conformation of GnRH and Its Analogs and the roles of individual amino acids in GnRH activity at the mammalian receptor are studied to derive conclusions about peptide structure-activity data.
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Inactivating KISS1 Mutation and Hypogonadotropic Hypogonadism
A. Kemal Topaloglu,Javier Tello,L. Damla Kotan,Mehmet Nuri Ozbek,M. Bertan Yılmaz,Seref Erdogan,Fatih Gurbuz,Fatih Temiz,Robert P. Millar,Bilgin Yüksel +9 more
TL;DR: An inactivating mutation in KISS1 in a large consanguineous family that results in failure of pubertal progression is described, indicating that functional kisspeptin is important for puberty and reproduction in humans.
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GnRHs and GnRH receptors
TL;DR: The ligand-receptor interactions and receptor conformational changes involved in receptor activation have been partly delineated and are setting the scene for generating novel selective GnRH analogues with potential for wider and more specific application.