R
Robin Ernst
Researcher at Janssen Pharmaceutica
Publications - 6
Citations - 119
Robin Ernst is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Epitope & Tau protein. The author has an hindex of 4, co-authored 6 publications receiving 86 citations.
Papers
More filters
Journal ArticleDOI
Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8.
Thomas J. Malia,Alexey Teplyakov,Robin Ernst,Sheng-Jiun Wu,Eilyn R. Lacy,Xuesong Liu,Marc Vandermeeren,Marc Mercken,Jinquan Luo,Raymond Sweet,Gary L. Gilliland +10 more
TL;DR: The phosphoepitope of AT8 was characterized through both peptide binding studies and costructures with phosphopeptides, and it was shown that AT8 bound to the triply phosphorylated tau peptide 30‐fold stronger than to the pS202/pT205 peptide, supporting the role of pS208 in AT8 recognition.
Journal ArticleDOI
Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Susan H. Tam,Stephen G. McCarthy,Anthony A. Armstrong,Sandeep Somani,Sheng-Jiun Wu,Xuesong Liu,Alexis Gervais,Robin Ernst,Dorina Saro,Rose Decker,Jinquan Luo,Gary L. Gilliland,Mark L. Chiu,Bernard Scallon +13 more
TL;DR: In this article, the authors reported on a human IgG2 variant with barely detectable activity in antibody-dependent cellular cytotoxicity, phagocytosis, complement activity, and Fcγ receptor binding assays.
Journal ArticleDOI
Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody.
Kristof Van Kolen,Thomas J. Malia,Clara Theunis,Rupesh Nanjunda,Alexey Teplyakov,Robin Ernst,Sheng-Jiun Wu,Jinquan Luo,M. Borgers,Marc Vandermeeren,Astrid Bottelbergs,Cindy Wintmolders,Eilyn R. Lacy,Hervé Maurin,Peter Larsen,Roland Willems,Tom Van De Casteele,Gallen Triana-Baltzer,Randy Slemmon,Wendy Galpern,John Q. Trojanowski,Hong Sun,Marc Mercken +22 more
TL;DR: In vitro experiments demonstrated a high intrinsic affinity for PT3 and hPT3 for AD brain-derived paired helical filaments but also to non-aggregated phospho (T212/T217) tau.
Journal ArticleDOI
In Pursuit of Stability Enhancement of a Prostate Cancer Targeting Antibody Derived from a Transgenic Animal Platform.
Sathyadevi Venkataramani,Robin Ernst,Mehabaw G. Derebe,Robert Wright,Jessica Kopenhaver,Steven Jacobs,Sanjaya Singh,Rajkumar Ganesan +7 more
TL;DR: In the quest for quality medicine, antibody engineering strategies to enhance the stability of PCa75 were pursued, with results that retained function while significantly improving the drug-like attributes of the molecule.
Patent
Antibodies Specifically Binding HLA-DR and Their Uses
Christian Martinez,Qiang Chen,Melissa Swiecki,Robert Kuhn,Hong Zhou,Karen E. Duffy,Stéphane Bécart,Chichi Huang,Xiefan Lin-Schmidt,Wu Sheng Jiun,Jinquan Luo,Galina Obmolova,Robin Ernst +12 more
TL;DR: In this article, the present invention relates antibodies or antigen-binding fragments thereof specifically binding HLA-DR, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.