Showing papers by "Robin M. Murray published in 1971"
TL;DR: Thirty-two patients presented to a renal unit with a history of prolonged analgesic abuse and no other obvious cause of renal damage, but the prognosis was much better in patients who ceased abuse of compound analgesics, and improvement could occur even in advanced renal failure.
Abstract: Over a five-year period 86 patients presented to a renal unit with a history of prolonged analgesic abuse and no other obvious cause of renal damage. Anaemia and peptic ulceration were common, and neurological states suggestive of chronic analgesic intoxication occurred in 22 patients. Thirty-two patients died during follow-up, but the prognosis was much better in patients who ceased abuse of compound analgesics, and improvement could occur even in advanced renal failure. While 84 patients had taken mixtures containing both aspirin and phenacetin, papillary necrosis was also found in two patients who had abused only aspirin, and when phenacetin was withdrawn from several leading compound analgesics, renal function continued to deteriorate in patients ingesting those preparations.
52 citations
TL;DR: Psychometric and psychiatric studies on eight patients who had abused compound analgesics containing phenacetin showed that four had definite evidence and two possible evidence of organic dementia, suggesting gross abuse of Phenacetin may overwhelm the antioxidant protection of the body, leading to premature deposition of lipofuscin and accelerated neuronal ageing.
44 citations