On the treatment of psoriasis

Essential oils are widely incorporated in cosmetic products, perfumes and related household products due to the variety of their properties but mainly due to their pleasant odour. The composition of these volatile natural complex mixtures may vary depending on the quality of plant material from which they were obtained and the extraction method by which they were derived. These factors are also important in ensuring the safe use of essential oils in personal care products. As they contain compounds with varied chemical structure and effects, skin sensitivity and irritations as well as other symptoms may arise after their application. Although essential oils are considered as safe and nontoxic when used at low concentrations, available scientific literature indicates that essential oils and their compounds may possess a strong allergy potential. This review focuses on side effects and allergy contact dermatitis caused by selected essential oils and their single compounds in cosmetic products, summarizing data from the most recent scientific literature.

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

Zinc is a key element for growth and development. In this narrative review, we focus on the role of dietary zinc in early life (including embryo, fetus and preterm neonate), analyzing consequences of zinc deficiency and adequacy of current recommendations on dietary zinc. We performed a systematic search of articles on the role of zinc in early life. We selected and analyzed 81 studies. Results of this analysis showed that preservation of zinc balance is of critical importance for the avoidance of possible consequences of low zinc levels on pre- and post-natal life. Insufficient quantities of zinc during embryogenesis may influence the final phenotype of all organs. Maternal zinc restriction during pregnancy influences fetal growth, while adequate zinc supplementation during pregnancy may result in a reduction of the risk of preterm birth. Preterm neonates are at particular risk to develop zinc deficiency due to a combination of different factors: (i) low body stores due to reduced time for placental transfer of zinc; (ii) increased endogenous losses; and (iii) marginal intake. Early diagnosis of zinc deficiency, through the measurement of serum zinc concentrations, may be essential to avoid severe prenatal and postnatal consequences in these patients. Typical clinical manifestations of zinc deficiency are growth impairment and dermatitis. Increasing data suggest that moderate zinc deficiency may have significant subclinical effects, increasing the risk of several complications typical of preterm neonates (i.e., necrotizing enterocolitis, chronic lung disease, and retinopathy), and that current recommended intakes should be revised to meet zinc requirements of extremely preterm neonates. Future studies evaluating the adequacy of current recommendations are advocated.

https://www.mdpi.com/2072-6643/7/12/5542/pdf

Zinc in Early Life: A Key Element in the Fetus and Preterm Neonate

The cosmetic ingredient Zinc Pyrithione (ZPT) (CAS No 13463-41-7, EC No 236-671-3) with the chemical name Bis[(2-pyridyl-1-oxo)-thio]zinc is currently regulated as a preservative in rinse-off products (excluding oral hygiene products) in a concentration up to 0.5% in general and up to 1.0% in hair products (Annex V/8). Furthermore, ZPT is also allowed in a concentration up to 0.1% in leave-on hair products (Annex Ш/101).

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Scientific Committee on Consumer Safety SCCS

Granuloma annulare (GA) is a poorly understood condition characterized by a set of clinical morphologic variants with 2 predominant histopathologic patterns of inflammation. This review provides a comprehensive overview of the available information about the clinical variants and histopathologic features, current epidemiologic data, and potential genetic underpinnings of GA. Much of the current understanding of GA is based on retrospective studies, case series, and case reports; this review aims to synthesize the available information and present it clearly for practicing dermatologists.

Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics

Methylmethacrylate was first reported in 1941 as a cause of contact dermatitis. Since then, occupational contact allergies to acrylates in dentistry, orthopedic surgery, printing industry and industry have been reported, but few reports are found in the literature as a consequence of the contact with sculptured artificial acrylic nails which are increasingly popular. We describe here 3 patients with contact allergy to acrylates in artificial sculptured nails. Patch tests were performed with the Portuguese baseline series of contact allergens and an extended series of acrylates were applied. In particular, we tested three female patients with allergic contact dermatitis from sculptured acrylic nails. Two of these patients were both customers and also technical nail beauticians. Two patients developed periungual eczema; one presented only with face and eyelid dermatitis had no other lesions. The tests showed positive reaction to 2-hydroxyethylmethacrylate (2-HEMA) and 2-hydroxypropylmethacrylate (2-HPMA) in all the three patients. Our cases demonstrate the variety of clinical presentations of allergic contact dermatitis from acrylic sculptured nails. They show the need to warn patients of persistent and sometimes permanent side effects of these products. They also emphasize the importance of cosmetic ingredient labeling.

Allergic Contact Dermatitis From Sculptured Acrylic Nails: Special Presentation With an Airborne Pattern

Auteur(s) : Ricardo Coelho1, Rodrigo Carvalho2, Ana Rodrigues2, Ana Afonso3, Jorge Cardoso2 1Dermatology Department, Hospital de Faro 2Dermatology Department, Hospital de Curry Cabral 3Pathology Department, Hospital de Curry Cabral A 74-year-old white woman was referred to our department with a 1-year history of four large asymptomatic lesions on her thighs. The lesions began as small erythematous patches and subsequently increased in diameter. She had a history of arthritis, treated [...]

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Patch-type granuloma annulare

Introduction: Several preservatives are currently allowed in cosmetic products in the EU. However, only a few of them are strongly represented on the market: formaldehyde, parabens, formaldehyde re...

Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit

Introduction Sculptured artificial acrylic nails are widely used in developed countries. Methylmethacrylate was first reported in 1941 as a cause of allergic contact dermatitis. Since then, occupational contact allergies to acrylates in dentistry, orthopedic surgery, printing industry and other industries have been reported. Objective We describe 3 patients with contact allergy to acrylates in artificial nails. Design and methods Patch tests with the Portuguese baseline series of contact allergens and an extended series of acrylates was applied. Results We observed three female patients with allergic contact dermatitis from sculptured acrylic nails. Two of these patients were both customers and also technical nail beauticians. Two patients developed periungual eczema; one patient presented only with eyelid dermatitis and no hand or periungual lesions. The tests showed positive reactions to 2-hydroxyethylmethacrylate (2-HEMA) and 2-hydroxypropylmethacrylate (2-HPMA) in three patients. Conclusion Our cases demonstrate the variety of clinical presentations of allergic contact dermatitis from acrylic nails. They show the need to warn patients of persistent and sometimes permanent side effects of these nails. They also emphasize the importance of cosmetic ingredient labeling.

Letter: Allergic contact dermatitis from sculptured acrylic nails: special presentation with a possible airborne pattern.

Panniculitis is a recognized, but rare complication of α1-antitrypsin (A1AT) deficiency Less than 60 cases have been reported, mostly in the homozygous PiZZ variant We report the case of a 55-year old woman with A1AT panniculitis associated with the heterozygous phenotype PiMS and discrete reduction of A1AT serum levels In addition, the pathophysiology of the disease, clinical and histopathological features, and current treatment possibilities are briefly reviewed

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Rodrigo Carvalho

Papers

Allergic Contact Dermatitis From Sculptured Acrylic Nails: Special Presentation With an Airborne Pattern

Patch-type granuloma annulare

Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit

Letter: Allergic contact dermatitis from sculptured acrylic nails: special presentation with a possible airborne pattern.

Alpha-1-antitrypsin deficiency-associated panniculitis: a case report.