Rodrigo M. Cordeiro

TL;DR: This study elucidates the mechanisms and the molecular level properties involving the reactive species produced during plasma application in cancer therapy as well as in photodynamic therapy, to kill cancer cells through membrane damage induced by nitro-oxidative stress.

TL;DR: In this article, the free energy barrier of reactive oxygen and nitrogen species (RONS) permeation across aldehyde-oxidized membrane was calculated using molecular dynamics simulations, and it was shown that hydrophilic RONS have relatively low barriers compared to hydrogen peroxide (H2O2) and hydroxyl radical (HO), and are more prone to permeate the membrane than for the native or peroxidised membranes.

TL;DR: The hypothesis according to which poration may be facilitated at the domain interface region of heterogeneous membranes is tested, but results were inconclusive due to their large statistical variance and sensitivity to simulation setup parameters.

TL;DR: In this article , the authors provide an overview of the current understanding of gap junction structure, function, and paradoxical pro-and anti-tumoral role in cancer, and discuss the treatment strategies to target these GJ properties for anti-cancer responses, via modulation of GJ function.