R
Roland A. Cooper
Researcher at Dominican University of California
Publications - 35
Citations - 1960
Roland A. Cooper is an academic researcher from Dominican University of California. The author has contributed to research in topics: Plasmodium falciparum & Chloroquine. The author has an hindex of 21, co-authored 35 publications receiving 1617 citations. Previous affiliations of Roland A. Cooper include Old Dominion University.
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Journal ArticleDOI
Multiple transporters associated with malaria parasite responses to chloroquine and quinine
Jianbing Mu,Michael T. Ferdig,Xiaorong Feng,Xiaorong Feng,Deirdre A. Joy,Junhui Duan,Tetsuya Furuya,G. Subramanian,L. Aravind,Roland A. Cooper,John C. Wootton,Momiao Xiong,Xin-zhuan Su +12 more
TL;DR: This study provides specific leads for better understanding of complex drug resistances in malaria parasites by searching for single nucleotide polymorphisms in DNA encoding 49 putative transporters and in 39 housekeeping genes that acted as negative controls.
Journal ArticleDOI
Discovery of dual function acridones as a new antimalarial chemotype.
Jane X. Kelly,Martin J. Smilkstein,Reto Brun,Sergio Wittlin,Roland A. Cooper,Kristin D. Lane,Kristin D. Lane,Aaron Janowsky,Aaron Janowsky,Robert A. Johnson,Robert A. Johnson,Rozalia Dodean,Rozalia Dodean,Rolf W. Winter,Rolf W. Winter,David J. Hinrichs,David J. Hinrichs,Michael K. Riscoe,Michael K. Riscoe,Michael K. Riscoe +19 more
TL;DR: This innovative acridone design merges intrinsic potency and resistance-counteracting functions in one molecule, and represents a new strategy to expand, enhance and sustain effective antimalarial drug combinations.
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Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
Carmony L. Hartwig,Andrew S. Rosenthal,John G. D'angelo,Carol E. Griffin,Gary H. Posner,Roland A. Cooper +5 more
TL;DR: It is proposed that the trioxane artemisinin and its derivatives are activated by heme-iron within the neutral lipid environment where they initiate oxidation reactions that damage parasite membranes.
Journal ArticleDOI
pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
TL;DR: It is proposed that the reconstruction of the evolutionary and molecular events underlying CQR is important at many levels, including its potential to assist in the development of rational approaches to thwart future drug resistances and the use of CQ-like compounds in drug combinations for new therapeutic approaches.
Journal ArticleDOI
Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine
Roland A. Cooper,Kristin D. Lane,Bingbing Deng,Jianbing Mu,Jigar Patel,Thomas E. Wellems,Xin-zhuan Su,Michael T. Ferdig +7 more
TL;DR: Results indicate that transmembrane segments 1, 4 and 9 of PfCRT provide important structural components of a substrate recognition and translocation domain and charge‐affecting mutations within these segments may affect the ability of Pf CRT to bind different quinoline drugs and determine their net accumulation in the DV.