Ronald T. Borchardt

TL;DR: In this paper, the peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases.

TL;DR: A compostos baseado em peptideos include aneis de tres membros contendo heteroatomo, inibindo seletivamente atividades especificas das hidrolases (Ntn) nucleofilicas N-terminais as mentioned in this paper.

TL;DR: A compound having a structure of formula II or a pharmaceutically acceptable salt thereof, wherein L is absent or is selected from C = O, C = S, and SO2, Q is absent from O, NH, and C 1-6 alkyl N, X is O is O; R 2 and R 4 each independently selected from c1-6-alkynyl, C1-8-alkyl, C 1 -6-hydroxyalkyl and aralkyl, any of which is optionally substituted with one or more substit

TL;DR: In this article, the authors present a base peptidique which comprennent des noyaux a trois elements, contenant des heteroatomes, and permettent d'inhiber de maniere efficace and selective des activites specifiques d'hydrolases nucleophiles.

TL;DR: In this paper, a base of peptides renferment au moins trois unites de peptide, un epoxyde ou une aziridine and une fonctionnalisation au niveau du terminal N.