Showing papers by "Roop K. Khar published in 2001"
TL;DR: Three Glycolamide esters of ibuprofen exhibited significantly better topical activity in carrageenan-induced rat paw edema assay and provided significant protection against inflammation when applied at a site remote to the inflammation site.
Abstract: Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of anti-inflammatory and analgesic activity but did not exhibit reduction in the ulcerogenicity on oral administration. However, all three exhibited significantly better topical activity in carrageenan-induced rat paw edema assay. In the same assay, they provided significant protection against inflammation when applied at a site remote to the inflammation site.
14 citations