R
Rosario Heck
Researcher at University of Mainz
Publications - 25
Citations - 556
Rosario Heck is an academic researcher from University of Mainz. The author has contributed to research in topics: Gene silencing & Regulation of gene expression. The author has an hindex of 12, co-authored 25 publications receiving 499 citations. Previous affiliations of Rosario Heck include Max Planck Society & Leipzig University.
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Isolation, biochemical characterization, long-term culture, and phenotype modulation of oval cells from carcinogen-fed rats.
TL;DR: Oval cells express phenotypic markers of liver parenchymal as well as bile duct epithelial cells and possess a certain intrinsic plasticity, and their potential to give rise to cholangiocellular and/or hepatocellular carcinomas will be verified in vivo.
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Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion.
Marco Poleganov,Sarah Eminli,Tim Beissert,Stephanie Herz,Jung-Il Moon,Johanna Goldmann,Arianne Beyer,Rosario Heck,Isabell Burkhart,Diana Barea Roldan,Özlem Türeci,Kevin Yi,Brad Hamilton,Ugur Sahin +13 more
TL;DR: A novel combination of RNAs enables the cell to tolerate repetitive transfections for the generation of stable iPS cell colonies from human fibroblasts within 11 days while requiring only four transfection, and the first known mRNA-vectored reprogramming of human blood-derived EPCs within 10 days while required only eight daily transfectations.
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Involvement of plasma membrane glycoproteins in the contact-dependent inhibition of growth of human fibroblasts
TL;DR: Data indicate that the growth of cells in vitro is regulated by specific cell-cell contacts, and shows that one of the molecular reactants in this process are membrane glycoproteins with asparagine-linked oligosaccharides.
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RNAi knock-down mice: an emerging technology for post-genomic functional genetics
Dirk Prawitt,L. Brixel,Christian Spangenberg,Leonid Eshkind,Rosario Heck,Franz Oesch,Bernhard Zabel,Ernesto Bockamp +7 more
TL;DR: A review of recent findings concerning the applicability of RNAi for regulating gene function in the mouse and prospective strategies as to how RNAi technology might be applied for generating conditional and tissue-restricted knock-down mice are presented.
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Measurement of lymphocyte proliferation: critical analysis of radioactive and photometric methods.
TL;DR: An optimized test protocol of the BrdU-ELISA which fulfills the requirements for a sensitive and practicable non-radioactive alternative to 3H-thymidine-test is presented.