Rosella Silvestrini

TL;DR: The results challenge the classical indication for primary mastectomy by showing that use of full-dose primary chemotherapy, sequentially combined with conservative surgery and radiation, can offer an effective and safe alternative to women concerned about the preservation of body integrity.

TL;DR: The predictive role of Bcl-2 expression on 6-year relapse-free and overall survival was mainly dependent on p53 expression.

TL;DR: Immunohistochemically detected p53 overexpression is an independent marker for shortened 6-year relapse-free and overall survival in node-negative patients with resectable breast cancers and should be used with other established prognostic factors, such as [3H]thymidine labeling index and estrogen receptor status, to further refine the prognostic assessment of node- negative breast cancer.

TL;DR: ‘DAUNOMYCIN’ is a new antibiotic isolated from the cultures of S. peucetius1 in the Farmitalia Research Laboratories and is easily obtained as hydrochloride in thin red needles melting at 184°–186° C.

TL;DR: The relevance of cell kinetics of the primary tumor as a marker of biologic aggressivity was verified on a series of 258 patients with operable breast cancer without nodal and distant metastases who underwent radical mastectomy, showing the relevance of the kinetic variable as an important prognostic marker in breast cancer.