R
Rüdiger Horstkorte
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 68
Citations - 1817
Rüdiger Horstkorte is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Sialic acid & Neural cell adhesion molecule. The author has an hindex of 18, co-authored 65 publications receiving 1549 citations. Previous affiliations of Rüdiger Horstkorte include Charité.
Papers
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Journal ArticleDOI
Sialylation is essential for early development in mice.
Martina Schwarzkopf,Klaus-Peter Knobeloch,Elvira Rohde,Stephan Hinderlich,Nicola Wiechens,Lothar Lucka,Ivan Horak,Werner Reutter,Rüdiger Horstkorte +8 more
TL;DR: It is reported that inactivation of the UDP-GlcNAc 2-epimerase by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development.
Journal ArticleDOI
Biochemical engineering of the N-acyl side chain of sialic acid: biological implications.
TL;DR: The side chain of sialic acid offers new tools to study its biological relevance and to exploit it as a tag for therapeutic and diagnostic applications as mentioned in this paper, including its crucial role for the interaction of different viruses with their sialylated host cell receptors.
Journal ArticleDOI
Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway.
TL;DR: Sialylation of over-expressed glycoproteins in all mammalian cell lines commonly used in biotechnology for the production of therapeutic glycoprotein is incomplete and there is a need for strategies leading to homogenous, naturally sialylated glyCoproteins.
Journal ArticleDOI
Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines.
TL;DR: MGE has intriguing biological consequences for treated cells (aliphatic MGE) and offers the opportunity to visualize the topography and dynamics of sialylated glycans in’vitro, ex vivo, and in”vivo (bioorthogonal MGE).
Book ChapterDOI
UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.
Stephan Hinderlich,Wenke Weidemann,Tal Yardeni,Tal Yardeni,Rüdiger Horstkorte,Marjan Huizing +5 more
TL;DR: An overview of structure, biochemistry, and genetics of the bifunctional enzyme and its complex regulation is given and diseases related to UDP-N-acetylglucosamine 2-epimerase/N- acetylmannosamine kinase are focused on.