A Review of Cyclopropenoid Compounds: Biological Effects of Some Derivatives

Practice of pharmacy

The ingestion of cyclopropenoid fatty acids by chicken and rats is known to produce several detrimental physiological effects. These effects are expressed as reduced growth, delayed sexual maturity, poor reproduction and a change in the makeup of the lipids in the body. In these studies albino rats were pair-fed purified diets to which various concentrations of S. foetida oil, a rich source of cyclopropenoid fatty acids, were added. Growth, fatty acid composition of various organs, sexual development and reproduction were studied. The cyclopropenoid fatty acids reduced growth when fed as 3$ of the oil~in the diet. Feed efficiency was reduced during the growing period of the rat; but when, body weight leveled off in adult rats, the feed efficiency approached that of the control group. Fatty acid composition was changed from the normal as reflected by a higher percentage of saturated fatty acids at the expense chiefly of the mono-unsaturated acids. There appeared to be an impairment in the fatty acyl desaturase enzyme system rather than an increased synthesis of saturated fatty acids. Sexual maturity, as determined by observing the age of perforation of the vaginal closure membrane, was significantly

Effects of ingestion of cyclopropenoid fatty acids on reproduction in thefemale rat

Ointment of mercuric nitrate

„Fette“ nennt man die ol- oder fettartigen, d. h. flussigen oder festen, in Pflanzensamen, Fruchtfleisch und im Tierkorper vorkommenden Glyzerinester der hoheren gesattigten und ungesattigten Fettsauren, also Verbindungen des 3 wertigen Alkohols Glyzerin C3H5(OH)3 mit Olsaure C18H34O2, Stearinsaure C18H36O2, Palmitinsaure C16H32O2, Linolsaure C18H32O2, Linolensaure C18H30O2 usw. Diese Ester haben die gemeinschaftliche Bezeichnung „Glyzeride“ . In der physiologischen Chemie fallen die Fette mit ahnlichen Stoffen oder solchen, welche sie begleiten, wie Lezithin, Cholesterinverbindungen usw. unter die gemeinschaftliche Bezeichnung „Lipoide“ .

Rudolph A. Kuever

Papers

Halphen's test improved

Ointment of mercuric nitrate

Cholesterol in Ointments

Scientific EditionsPhenolic ointments