https://www.annalsthoracicsurgery.org/article/S0003-4975(10)64887-4/pdf

Comparative Evaluation of a New Disposable Rotating Membrane Oxygenator with Bubble Oxygenator

A new project is presented, the pumping oxygenator, functionally integrating pulsatile pumping and blood oxygenation in a single device. Solid, semipermeable silicone membranes allow gas exchange and simultaneously transfer energy from pressurized gas to blood thanks to their distensibility and to inlet and outlet 1-way valves. Two small-sized (1 m2 exchange surface area) prototypes were designed, constructed, hydraulically characterized, and subjected to gas transfer evaluation tests. Blood flow rates (Qb) up to 1,250 ml/min were obtained with 30 mm Hg static preload and 130 mm Hg afterload with 0.7 m upstream and 2.1 m downstream 3/8 inch pipes. Physiological oxygen transfer (V o2 = 5 ml/dl, ml of transferred O2/dl of treated blood) was delivered at Qb < 900 ml/min, about 4 ml/dl at Qb = 1,250 ml/min. V o2 also was significantly increased by increasing percent systolic time. CO2 transfer decreased regularly with increasing Qb from V co2 = 4.8 ml/dl at Qb = 400 ml/min to V co2 = 2.1 ml/dl at Qb = 1,250 ml/min. The results confirm the possibility of integrating oxygenation and pulsatile pumping. The pumping oxygenator represents a promising project deserving further improvements.

The pumping oxygenator: design criteria and first in vitro results.

Laboratory evaluation of a new silicone membrane oxygenator.

The volume of red blood corpuscles is constant under normal conditions and follows the law of Gauss’s distribution of a population. Thus an alteration of the volume of the erythrocytes is of pathophysiological significance.

Rush Bf

Papers

A pulsatile flow membrane oxygenator.