R
Ryuichi Tatsumi
Researcher at Kyushu University
Publications - 94
Citations - 3868
Ryuichi Tatsumi is an academic researcher from Kyushu University. The author has contributed to research in topics: Skeletal muscle & Hepatocyte growth factor. The author has an hindex of 28, co-authored 88 publications receiving 3552 citations. Previous affiliations of Ryuichi Tatsumi include Hokkaido University.
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Journal ArticleDOI
HGF/SF Is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells☆
TL;DR: It is demonstrated that hepatocyte growth factor/scatter factor is present in muscle, can be released upon injury, and has the ability to activate quiescent satellite cells in vivo.
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Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide.
TL;DR: It is indicated that stretch triggers an intracellular cascade of events, including nitric oxide synthesis, which results in HGF release and satellite cell activation.
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Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor.
Ryuichi Tatsumi,Xiaosong Liu,Antonio Pulido,Mark Morales,Tomowa Sakata,Sharon M. Dial,Akihito Hattori,Yoshihide Ikeuchi,Ronald E. Allen +8 more
TL;DR: Stretching muscle liberates HGF in a NO-dependent manner, which can activate satellite cells, and the activity of stretched muscle extract was abolished by L-NAME treatment but could be restored by the addition of HGF, indicating that the extract was not inhibitory.
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Mechanical stretch induces activation of skeletal muscle satellite cells in vitro
TL;DR: These experiments suggest that HGF may be involved in linking mechanical perturbation of muscle to satellite cell activation, and appeared to cause release of preexisting HGF from the extracellular matrix.
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HGF is an autocrine growth factor for skeletal muscle satellite cells in vitro.
TL;DR: It is shown that HGF is expressed by cultured satellite cells and that endogenous HGF from satellite cells can act in an autocrine fashion, and direct administration of HGF into damaged muscle may represent a potentially useful approach for stimulating muscle repair.