https://escholarship.org/content/qt6nx7k5zw/qt6nx7k5zw.pdf?t=qlup1r

Lipidomics reveals a remarkable diversity of lipids in human plasma

Lean red meats are: • An excellent source of high biological value protein, vitamin B12, niacin, vitamin B6, iron, zinc and phosphorus • A source of long-chain omega-3 polyunsaturated fats, riboflavin, pantothenic acid, selenium and possibly also vitamin D • Mostly low in fat and sodium • Sources of a range of endogenous antioxidants and other bioactive substances including taurine, carnitine, carnosine, ubiquinone, glutathione and creatine.

/pdf/nutritional-composition-of-red-meat-16u6fhx1ah.pdf

Nutritional composition of red meat

Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 (CoQ10) are reviewed in this paper. CoQ10 has a fundamental role in cellular bioenergetics. CoQ10 is also an import...

Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics.

Objective: Our objective was to assess effects of dietary supplementation with coenzyme Q10 (CoQ) on blood pressure and glycaemic control in subjects with type 2 diabetes, and to consider oxidative stress as a potential mechanism for any effects. Subjects and design: Seventy-four subjects with uncomplicated type 2 diabetes and dyslipidaemia were involved in a randomised double blind placebo-controlled 2×2 factorial intervention. Setting: The study was performed at the University of Western Australia, Department of Medicine at Royal Perth Hospital, Australia. Interventions: Subjects were randomly assigned to receive an oral dose of 100 mg CoQ twice daily (200 mg/day), 200 mg fenofibrate each morning, both or neither for 12 weeks. Main outcome measures: We report an analysis and discussion of the effects of CoQ on blood pressure, on long-term glycaemic control measured by glycated haemoglobin (HbA1c), and on oxidative stress assessed by measurement of plasma F2-isoprostanes. Results: Fenofibrate did not alter blood pressure, HbA1c, or plasma F2-isoprostanes. There was a 3-fold increase in plasma CoQ concentration (3.4±0.3 µmol/l, P<0.001) as a result of CoQ supplementation. The main effect of CoQ was to significantly decrease systolic (−6.1±2.6 mmHg, P=0.021) and diastolic (−2.9±1.4 mmHg, P=0.048) blood pressure and HbA1c (−0.37±0.17%, P=0.032). Plasma F2-isoprostane concentrations were not altered by CoQ (0.14±0.15 nmol/l, P=0.345). Conclusions: These results show that CoQ supplementation may improve blood pressure and long-term glycaemic control in subjects with type 2 diabetes, but these improvements were not associated with reduced oxidative stress, as assessed by F2-isoprostanes. Sponsorship: This study was supported by a grant from the NH&MRC, Australia.

Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes

https://www.grc.com/sr6dev/misc/coq10/Plasma%20coenzyme%20Q10%20response%20to%20oral%20ingestion%20of%20coenzyme%20Q10%20formulations.pdf

Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations.

The literature concerning the importance of coenzyme Q10 in health and disease has been reviewed. Usual dietary intake together with normal in vivo synthesis seems to fulfil the demands for Q10 in healthy individuals. The importance of Q10 supplementation for general health has not been investigated in controlled experiments. The literature allows no firm conclusions about the significance of Q10 in physical activity. In different cardiovascular diseases, including cardiomyopathy, relatively low levels of Q10 in myocardial tissue have been reported. Positive clinical and haemodynamic effects of oral Q10 supplementation have been observed in double-blind trials, especially in chronic heart failure. These effects should be further examined. No important adverse effects have been reported from experiments using daily supplements of up to 200 mg Q10 for 6-12 months and 100 mg daily for up to 6 y.

Coenzyme Q10 in health and disease.

The literature concerning the importance of Q10 for health and disease has been reviewed. Dietary intake together with normal in vivo synthesis seems to fulfil the body's demands for Q10 in younger, healthy individuals. The importance of Q10 in general well-being has not been investigated in controlled experiments. The literature allows no firm conclusions about the significance of Q10 in physical activity. In different cardiovascular diseases a positive effect of oral Q10 supplementation has been reported, especially in chronic heart failure. These effects should be further examined. No important adverse side effects have been reported from experiments using daily supplements of up to 200 mg of Q10 for six to twelve months, and 100 mg daily for up to six years.

S. A. Mortensen

Papers

Coenzyme Q10 in health and disease.

Efficacy and safety of dietary supplementation containing Q10