A series of ethyl 7-cyclopropyl-2-(arylamino)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (9a-d) were prepared by coupling of ethyl 7-cyclopropyl-2-chloro-3-nitro-4-oxo-4,7-dihydro...

Palladium-catalyzed amination of 2-chlorothienopyridone with primary aromatic amines

4,7-Dihydrothieno[2,3-b]pyridine 4 and thieno[2,3-b]pyridine 6 were obtained by Thorpe–Ziegler cyclization. Mn(OAc)3/acetic acid system had been used for oxidation of 1,4-dihydropyridine 3 to pyridine derivative 5. 6-Carbamoylmethylsulfanyl-1,4-dihydropyridine 3 was prepared by alkylation of piperidinium 1,4-dihydropyridine-2-thiolate 1 with iodoacetamide.

https://content.sciendo.com/downloadpdf/journals/ljc/51/1-2/article-p143.pdf

S. S. Sabri

Papers

Thienopyridone Antibacterials. Part 1. A Synthesis of Some 7‐Alkyl‐2‐ chloro‐1,4‐dihydro‐4‐oxothieno(2,3‐b)pyridine‐5‐carboxylic Acids.